CAS 778611-78-2
:N2-Benzyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite
Description:
N2-Benzyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite is a modified nucleoside derivative used primarily in the field of nucleic acid chemistry, particularly for the synthesis of oligonucleotides. This compound features a guanosine base, which is one of the four nucleobases in RNA, and is modified at the 2' and 5' positions to enhance stability and facilitate the synthesis process. The presence of the tert-butyldimethylsilyl (TBDMS) group at the 2' position provides protection against unwanted reactions during oligonucleotide synthesis, while the dimethoxytrityl (DMT) group at the 5' position serves as a protective group that can be removed to allow for further coupling reactions. The phosphoramidite functionality is crucial for the stepwise addition of nucleotides in automated synthesizers. Overall, this compound is characterized by its stability, reactivity, and utility in producing modified RNA sequences for research and therapeutic applications.
Formula:C53H68N7O8PSi
Synonyms:- N2-Benzyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite
- Guanosine, 5'-O-[bis(4-methoxyphenyl)phenylmethyl]-2'-O-[(1,1-dimethylethyl)dimethylsilyl]-N-(phenylmethyl)-, 3'-[2-cyanoethyl bis(1-methylethyl)phosphoramidite] (9CI)
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Found 1 products.
N2-Benzyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite
CAS:<p>N2-Benzyl-2'-O-tert-butyldimethylsilyl-5'-O-DMT-guanosine 3'-CE phosphoramidite is a nucleoside which is the phosphate ester of guanosine. It is synthesized from N4-benzoylcytidine 5'-O-DMT phosphoramidite and 2'O,N-bis(tertiarybutyl)dimethylsilylguanosine 3'-Ce phosphoramidite. The product is used in the synthesis of deoxyribonucleosides and as an activator for ribonucleosides. It has anticancer, antiviral, and antimalarial activities.</p>Purity:Min. 95%
