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CAS 77879-89-1

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Gilvocarcin M

Description:
Gilvocarcin M is a natural product belonging to the class of anthracycline antibiotics, primarily derived from the bacterium Micromonospora. It exhibits notable antitumor activity, making it of interest in cancer research and potential therapeutic applications. The compound is characterized by its complex polycyclic structure, which contributes to its biological activity. Gilvocarcin M functions by intercalating into DNA, thereby disrupting the replication process and ultimately leading to cell death. Its mechanism of action is similar to that of other anthracyclines, but it has distinct structural features that may influence its efficacy and side effect profile. Additionally, Gilvocarcin M has shown activity against a variety of cancer cell lines, indicating its potential as a chemotherapeutic agent. However, like many antibiotics, it may also exhibit toxicity, necessitating careful consideration in clinical applications. Research continues to explore its full potential, including its pharmacokinetics, optimal dosing strategies, and combination therapies to enhance its effectiveness while minimizing adverse effects.
Formula:C26H26O9
InChI:InChI=1S/C26H26O9/c1-10-7-14-18(16(8-10)32-3)13-9-17(33-4)20-15(28)6-5-12(19(20)24(13)35-26(14)31)25-22(30)21(29)23(34-25)11(2)27/h5-9,11,21-23,25,27-30H,1-4H3/t11-,21-,22-,23+,25-/m1/s1
InChI key:InChIKey=BYFOTBZTKXSZHH-FUCVEXJHSA-N
SMILES:O(C)C1=C2C(=C3C(C=4C(C(=O)O3)=CC(C)=CC4OC)=C1)C(=CC=C2O)[C@H]5O[C@@]([C@@H](C)O)([C@H](O)[C@H]5O)[H]
Synonyms:
  • Antibiotic 1072A
  • 6H-Benzo[d]naphtho[1,2-b]pyran-6-one, 4-(6-deoxy-α-D-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-
  • Gilvocarcin M
  • 4-(6-Deoxy-α-D-galactofuranosyl)-1-hydroxy-10,12-dimethoxy-8-methyl-6H-benzo[d]naphtho[1,2-b]pyran-6-one
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