CAS 779353-01-4

Dinaciclib

Description:

Dinaciclib is a small molecule inhibitor primarily targeting cyclin-dependent kinases (CDKs), particularly CDK1, CDK2, CDK5, and CDK9, which play crucial roles in cell cycle regulation and transcription. It is classified as an antineoplastic agent and is primarily investigated for its potential in cancer therapy, particularly in hematological malignancies and solid tumors. Dinaciclib exhibits a mechanism of action that involves the inhibition of CDK activity, leading to cell cycle arrest and apoptosis in cancer cells. The compound is typically administered intravenously and has shown promise in preclinical and clinical studies, although its use may be associated with side effects such as myelosuppression and gastrointestinal disturbances. Its chemical structure features a complex arrangement that contributes to its specificity and potency as a CDK inhibitor. Ongoing research continues to explore its efficacy in combination with other therapeutic agents to enhance treatment outcomes in various cancer types.

Formula: C₂₁H₂₈N₆O₂

InChI: InChI=1S/C21H28N6O2/c1-2-17-14-23-27-19(22-13-16-6-5-9-25(29)15-16)12-20(24-21(17)27)26-10-4-3-7-18(26)8-11-28/h5-6,9,12,14-15,18,22,28H,2-4,7-8,10-11,13H2,1H3/t18-/m0/s1

InChI key: InChIKey=PIMQWRZWLQKKBJ-SFHVURJKSA-N

SMILES: N(CC1=CN(=O)=CC=C1)C=2N3C(N=C(C2)N4[C@H](CCO)CCCC4)=C(CC)C=N3

Synonyms:

• Dinaciclib
• Sch 727965
• 2-[(2S)-1-[3-Ethyl-7-[(1-oxidopyridin-1-ium-3-yl)methylamino]pyrazolo[1,5-a]pyrimidin-5-yl]piperidin-2-yl]ethanol
• (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol
• 2-Piperidineethanol, 1-[3-ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-, (2S)-
• PS-095760
• (2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol Dinaciclib (SCH727965)
• 3-[({8-ethyl-2-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrrolo[1,2-a]pyriMidin-4-yl}aMino)Methyl]pyridin-1-iuM-1-olate
• Dinaciclib (SCH 727965)
• (S)-3-((3-ethyl-5-(2-(2-hydroxyethyl)piperidin-1-yl)pyrazolo[1,5-a]pyriMidin-7-ylaMino)Methyl)pyridine 1-oxide

(2S)-1-[3-Ethyl-7-[[(1-oxido-3-pyridinyl)methyl]amino]pyrazolo[1,5-a]pyrimidin-5-yl]-2-piperidineethanol

CAS: 779353-01-4

Formula: C₂₁H₂₈N₆O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 396.4860

Ref: IN-DA003AK1

Dinaciclib

CAS: 779353-01-4

Formula: C₂₁H₂₈N₆O₂

Molecular weight: 396.50

Ref: 4Z-D-171001

Dinaciclib

CAS: 779353-01-4

Dinaciclib

Purity: ≥98%

Molecular weight: 396.49g/mol

Ref: 54-BUP14478

(S)-3-(((3-Ethyl-5-(2-(2-Hydroxyethyl)Piperidin-1-Yl)Pyrazolo[1,5-A]Pyrimidin-7-Yl)Amino)Methyl)Pyridine 1-Oxide

CAS: 779353-01-4

(S)-3-(((3-Ethyl-5-(2-(2-Hydroxyethyl)Piperidin-1-Yl)Pyrazolo[1,5-A]Pyrimidin-7-Yl)Amino)Methyl)Pyridine 1-Oxide

Purity: 98%

Molecular weight: 396.49g/mol

Ref: 54-OR1023108

Dinaciclib

CAS: 779353-01-4

Formula: C₂₁H₂₈N₆O₂

Purity: ≥ 98.0%

Color and Shape: Light brown to brown solid

Molecular weight: 396.49

Ref: 7W-GX1180

Dinaciclib

CAS: 779353-01-4

Dinaciclib (SCH 727965) is a CDK inhibitor that selectively inhibits CDK1, CDK2, CDK5, and CDK9 (IC50 = 3/1/1/4 nM).

Formula: C₂₁H₂₈N₆O₂

Purity: 98.21% - 99.75%

Color and Shape: Solid

Molecular weight: 396.49

Ref: TM-T1912

Dinaciclib

CAS: 779353-01-4

Dinaciclib is a potent, selective inhibitor of the cancer-associated protein kinase AXL. It inhibits the downstream signaling pathway of the neurokinin-1 receptor (NKR), which plays an important role in cancer development. Dinaciclib has been shown to inhibit tumor growth in vitro and in vivo, as well as decrease the expression of MCL-1 protein. This drug also inhibits mitochondrial membrane potential and potentiates the antitumor response by combining with other chemotherapeutic agents.

Formula: C₂₁H₂₈N₆O₂

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 396.49 g/mol

Ref: 3D-FD158760

Dinaciclib

CAS: 779353-01-4

Purity: 98%

Molecular weight: 396.227

Ref: 10-F808704

Dinaciclib

Controlled Product

CAS: 779353-01-4

Stability Hygroscopic
Applications Dinaciclib is a potent and selective inhibitor of cyclin-dependent kinases which is undergoing development as oncology therapeutics.
References Paruch, K., et al.: ACS. Med. Chem. Lett., 1, 204 (2010); Zhang, Da., et al.: Cancer. Chemotherap. Pharmacol., 70, 891 (2012); Chen, S., et al.: Cancer. Res., 72, 4225 (2012);

Formula: C₂₁H₂₈N₆O₂

Color and Shape: Neat

Molecular weight: 396.49

Ref: TR-D479725