CAS 7803-88-5

O-Methylguanosine

Description:

O-Methylguanosine is a modified nucleoside, specifically a derivative of guanosine, where a methoxy group is attached to the oxygen atom at the 7-position of the guanine base. This modification can influence the stability and functionality of RNA molecules, particularly in the context of post-transcriptional modifications. O-Methylguanosine is often found in various biological systems, including tRNA and rRNA, where it plays a role in the proper folding and function of these molecules. The presence of the methoxy group can enhance the resistance of RNA to enzymatic degradation, thereby contributing to the stability of RNA structures. In terms of solubility, O-Methylguanosine is generally soluble in water and polar solvents, making it accessible for various biochemical applications. Its unique structural characteristics allow it to participate in specific interactions within nucleic acids, influencing processes such as translation and gene expression. Overall, O-Methylguanosine is an important component in the study of RNA biology and the understanding of nucleoside modifications.

Formula: C₁₁H₁₅N₅O₅

InChI: InChI=1S/C11H15N5O5/c1-20-9-5-8(14-11(12)15-9)16(3-13-5)10-7(19)6(18)4(2-17)21-10/h3-4,6-7,10,17-19H,2H2,1H3,(H2,12,14,15)/t4-,6-,7-,10-/m1/s1

InChI key: InChIKey=IXOXBSCIXZEQEQ-KQYNXXCUSA-N

SMILES: O[C@H]1[C@H](N2C=3C(N=C2)=C(OC)N=C(N)N3)O[C@H](CO)[C@H]1O

Synonyms:

• 2-Amino-6-methoxypurine ribonucleoside
• 6-Methoxy-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-9H-purin-2-amine
• 6-Methylguanosine
• 6-O-Methylguanosine
• 9H-Purine, 2-amino-6-methoxy-9-β-<span class="text-smallcaps">D</span>-ribofuranosyl-
• 9H-purin-2-amine, 6-methoxy-9-beta-D-ribofuranosyl-
• Guanosine, 6-O-methyl-
• NSC 66381
• O-Methylguanosine
• O⁶-Methylguanosine
• 6-Methoxy-9-β-D-ribofuranosyl-9H-purin-2-amine

6-O-Methyl Guanosine 

CAS: 7803-88-5

Formula: C₁₁H₁₅N₅O₅

Purity: 98%

Color and Shape: Solid

Molecular weight: 297.2673

Ref: IN-DA005DOY

O6-Methylguanosine

CAS: 7803-88-5

Formula: C₁₁H₁₅N₅O₅

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 297.27

Ref: 7W-GN6118

6-O-Methyl Guanosine

CAS: 7803-88-5

6-O-Methyl Guanosine

Purity: ≥95%

Molecular weight: 297.27g/mol

Ref: 54-BUP11165

6-O-Methyl Guanosine

CAS: 7803-88-5

Formula: C₁₁H₁₅N₅O₅

Molecular weight: 297.27

Ref: 4Z-G-2449

6-O-Methyl Guanosine

CAS: 7803-88-5

6-O-Methyl Guanosine inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line.

Formula: C₁₁H₁₅N₅O₅

Purity: 97.5%

Color and Shape: Solid

Molecular weight: 297.27

Ref: TM-T7491

6-O-Methyl Guanosine-d4 (major)

Controlled Product

CAS: 7803-88-5

Formula: C₁₁H₁₁D₄N₅O₅

Color and Shape: Neat

Molecular weight: 301.29

Ref: TR-M311832

6-O-Methyl Guanosine

Controlled Product

CAS: 7803-88-5

Applications A guanine derivative that acts as modulators of GTPases and modulator-resistant enzymes; used in drug design and target validation.
References Goth-Goldstein, R., et al.: Cancer Res., 40, 2623 (1980), Nakabeppu, Y., et al.: J. Biol. Chem., 259, 13723 (1984), Modrich, P., et al.: Science, 266, 1959 (1994),

Formula: C₁₁H₁₅N₅O₅

Color and Shape: White

Molecular weight: 297.27

Ref: TR-M311830

O6-Methylguanosine

CAS: 7803-88-5

Intermediate in the synthesis of nelarabine

Formula: C₁₁H₁₅N₅O₅

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 297.27 g/mol

Ref: 3D-NM02922

Nelarabine Impurity 12

CAS: 7803-88-5

Formula: C₁₁H₁₅N₅O₅

Molecular weight: 297.27

Ref: ST-EA-CP-N38012