CAS 78080-27-0

9H-Imidazo[1,2-a]purin-9-one,3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-b-D-ribofuranosyl)- (9CI)

Description:

9H-Imidazo[1,2-a]purin-9-one, 3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-b-D-ribofuranosyl)- (9CI), with the CAS number 78080-27-0, is a complex organic compound that belongs to the class of purine derivatives. This substance features an imidazole ring fused to a purine structure, which is characteristic of many biologically active molecules. The presence of a phenyl group and a ribofuranosyl moiety suggests potential interactions with biological systems, particularly in nucleic acid chemistry and enzyme inhibition. The phosphinico group indicates that this compound may exhibit properties relevant to phosphorylation processes, which are crucial in cellular signaling and metabolism. Its structural complexity allows for various potential applications in medicinal chemistry, particularly in the development of antiviral or anticancer agents. The compound's solubility, stability, and reactivity would depend on the specific conditions, including pH and solvent, making it a subject of interest for further research in pharmacology and biochemistry.

Formula: C₁₈H₁₅N₅NaO₇P

Synonyms:

• b-Phenyl-1,N2-ethenoguanosine cyclic 3',5'-phosphate
• 4H-Furo[3,2-d]-1,3,2-dioxaphosphorin,9H-imidazo[1,2-a]purin-9-one deriv.
• 1,N2-PET-cGMP
• 3-[(4aR,6R,7R,7aS)-7-hydroxy-2-oxido-2-oxo-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-6-yl]-6-phenyl-5H-imidazo[1,2-a]purin-9-one
• PET-CGMP
• BETA-PHENYL-1,N2-ETHENOGUANOSINE-3',5'-MONOPHOSPHATE SODIUM SALT
• β-Phenyl-1,N2-ethenoguanosine 3μ,5μ-monophosphate sodium salt
• BETA-PHENYL-1,N2-ETHENOGUANOSINE-3',5'-CYCLIC MONOPHOSPHATE SODIUM SALT
• PET-CGMP SODIUM SALT
• ?phenyl-1,n?ethenoguanosine-3’,5’-cyclicmonophosphate(pet-cgmp),sodiumsalt
• 9H-Imidazo[1,2-a]purin-9-one,3,4-dihydro-6-phenyl-3-(3,5-O-phosphinico-b-D-ribofuranosyl)- (9CI)

PET-cGMP

CAS: 78080-27-0

PET-cGMP is an analog of the endogenous cGMP that is synthesized by cells in the gut. PET-cGMP binds to the G protein-coupled receptor and activates cyclase or phosphodiesterase, leading to increased levels of intracellular cAMP or cGMP. This analog has been shown to be effective in inhibiting vasoactive intestinal peptide (VIP) from activating the enzyme myosin phosphatase and guanylate cyclase inhibitor. PET-cGMP has also been shown to have a potent inhibitory effect on cyclic nucleotide phosphodiesterase, which degrades cAMP and cGMP. The effects of PET-cGMP on these enzymes may be due to its ability to bind with high affinity to t84 cells, confocal microscope, and mesenteric tissues.

Formula: C₁₈H₁₅N₅NaO₇P

Purity: Min. 95%

Molecular weight: 467.3 g/mol

Ref: 3D-DDA08027

PET-cGMP

CAS: 78080-27-0

PET-cGMP is an analogue of cyclic guanosine monophosphate and functions as a potent, selective agonist for PKGI. It exhibits an EC50 of 3.8 nM for PKGIβ and 193 nM for PKGII.

Formula: C₁₈H₁₆N₅O₇P

Color and Shape: Solid

Molecular weight: 445.323

Ref: TM-T204785