CAS 78090-11-6

Picoprazole

Description:

Picoprazole is a chemical compound classified as a proton pump inhibitor (PPI), primarily used for its ability to reduce gastric acid secretion. It is characterized by its specific mechanism of action, which involves the irreversible inhibition of the H+/K+ ATPase enzyme in the gastric parietal cells, leading to decreased acid production. This property makes it effective in treating conditions such as gastroesophageal reflux disease (GERD) and peptic ulcers. Picoprazole is typically administered orally and is known for its relatively long half-life, allowing for once-daily dosing in therapeutic regimens. The compound exhibits good solubility in various solvents, which aids in its formulation for pharmaceutical use. Additionally, it has a favorable safety profile, with side effects generally being mild and manageable. As with other PPIs, long-term use may be associated with certain risks, such as nutrient malabsorption and gastrointestinal infections. Overall, Picoprazole represents a significant advancement in the management of acid-related disorders.

Formula: C₁₇H₁₇N₃O₃S

InChI: InChI=1/C17H17N3O3S/c1-10-5-4-6-18-15(10)9-24(22)17-19-13-7-11(2)12(16(21)23-3)8-14(13)20-17/h4-8H,9H2,1-3H3,(H,19,20)

SMILES: Cc1cccnc1CS(=O)c1nc2cc(C)c(cc2[nH]1)C(=O)OC

Synonyms:

• Picoprazole [INN]
• Methyl 6-methyl-2-(((3-methyl-2-pyridyl)methyl)sulfinyl)-5-benzimidazolecarboxylate
• Picoprazol
• Picoprazol [INN-Spanish]
• Picoprazolum
• Picoprazolum [INN-Latin]
• 1H-Benzimidazole-5-carboxylic acid, 6-methyl-2-(((3-methyl-2-pyridinyl)methyl)sulfinyl)-, methyl ester
• methyl 6-methyl-2-{[(3-methylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole-5-carboxylate

Picoprazole

Controlled Product

CAS: 78090-11-6

Applications Picoprazole is gastric hydrogen ion-potassium ATPase inhibitor.
References Fellenius, E., et al.: Nature, 290, 159 (1981); Morii, M., et al.: Biochem. Pharmacol., 39, 661 (1990);

Formula: C₁₇H₁₇N₃O₃S

Color and Shape: Neat

Molecular weight: 343.4

Ref: TR-P437608

Picoprazole

CAS: 78090-11-6

Picoprazole is a proton pump inhibitor that blocks the H+/K+ ATPase in the gastric parietal cells, reducing the acidity of the stomach. It is used to prevent and treat duodenal ulcers and other conditions where there may be excess stomach acid production. Picoprazole is also used to prevent stress ulcers, which are ulcers caused by damage from surgery or burns. The drug inhibits the growth of cancer cells in animals, but it has not been approved for this use. Picoprazole has a molecular weight of 345.3 Da and an acidic pH of 1-2.

Formula: C₁₇H₁₇N₃O₃S

Purity: Min. 95%

Molecular weight: 343.4 g/mol

Ref: 3D-DDA09011

Picoprazole

CAS: 78090-11-6

Picoprazole is a specific H+/K+-ATPase inhibitor (IC50 of 3.1±0.4 μM).

Formula: C₁₇H₁₇N₃O₃S

Purity: 98%

Color and Shape: Solid

Molecular weight: 343.4

Ref: TM-T12471