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CAS 78103-18-1

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Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-Methylbenzoate) (Decitabine IMpurity)

Description:
Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-Methylbenzoate), commonly referred to as Decitabine Impurity, is a chemical compound with the CAS number 78103-18-1. This substance is a derivative of a sugar molecule, specifically a methylated form of 2-deoxy-D-erythro-pentopyranoside, which is a pentose sugar. The presence of bis(4-methylbenzoate) indicates that the compound has two ester functional groups derived from p-toluic acid, contributing to its chemical properties. Typically, such compounds may exhibit characteristics like moderate solubility in organic solvents and potential reactivity due to the ester groups. In the context of pharmaceuticals, impurities like this can arise during the synthesis of active pharmaceutical ingredients and may influence the efficacy and safety profiles of the final product. Understanding the characteristics of such impurities is crucial for quality control and regulatory compliance in drug development.
Formula:C22H24O6
Synonyms:
  • Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-Methylbenzoate) (Decitabine IMpurity)
  • UKFSGKLSXCFJNM-UHFFFAOYSA-N
  • D-erythro-Pentopyranoside, methyl 2-deoxy-, 3,4-bis(4-methylbenzoate)
  • Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-methylbenzoate)
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  • Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-methylbenzoate)(Decitabine Impurity)
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    Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-methylbenzoate)(Decitabine Impurity)

    Controlled Product
    CAS:

    Applications Methyl 2-Deoxy-D-erythro-pentopyranoside Bis(4-methylbenzoate) is an impurity of Decitabine (α-isomer: D226730), a DNA hypomethylating agent that is used to treat various forms of cancer, such as myelogeneous leukemia and metastatic lung cancerBy inhibiting DNA methyltransferase, Decitabine silences the tumour suppressor genes and, consequently, “normalizing” gene expression in cancerous cells.
    References Aribi, A., et al.: Cancer, 109, 713 (2007); Issa, J., et al.: Blood, 103, 1635 (2004); Kantarjian , H., et al.: Cancer, 98, 522 (2003); Momparler, R., et al.: Anti-Cancer Drug., 8, 358 (1997); Plimack, E., et al.: Leukemia Lymphoma, 48, 1472 (2007)

    Formula:C22H24O6
    Color and Shape:Neat
    Molecular weight:384.422

    Ref: TR-M296215

    10g
    1,509.00€