CAS 78123-71-4

damgo

Description:

DAMGO, or [D-Ala2, N-Me-Phe4, Gly5]-enkephalin, is a synthetic peptide that acts as a selective agonist for the mu-opioid receptor. It is characterized by its specific amino acid sequence, which contributes to its high affinity and potency in binding to opioid receptors, leading to analgesic effects. DAMGO is often used in research to study pain mechanisms and the pharmacological properties of opioid receptors. Its structure includes modifications that enhance its stability and receptor selectivity compared to natural enkephalins. The compound is typically administered in laboratory settings for experimental purposes, and its effects can include modulation of pain perception, sedation, and potential for addiction, similar to other opioids. Safety and ethical considerations are paramount when handling DAMGO, as it is associated with the opioid class of drugs, which can have significant physiological effects and potential for misuse.

Formula: C₂₆H₃₅N₅O₆

InChI: InChI=1/C26H35N5O6/c1-17(30-25(36)21(27)14-19-8-10-20(33)11-9-19)24(35)29-16-23(34)31(2)22(26(37)28-12-13-32)15-18-6-4-3-5-7-18/h3-11,17,21-22,32-33H,12-16,27H2,1-2H3,(H,28,37)(H,29,35)(H,30,36)/t17-,21+,22+/m1/s1

Synonyms:

• Enkephalin, ala(2)-mephe(4)-gly(5)-
• (D-Ala(2)-mephe(4)-gly-ol(5))enkephalin
• 2-Ala-4-mephe-5-gly-enkephalin
• Ala(2)-mephe(4)-gly-ol(5) enkephalin
• Dago
• Damge
• Dagol
• Enkephalin, Ala(2)-MePhe(4)-Gly-ol(5)-
• Enkephalin, alanyl(2)-methylphenylalanyl(4)-glycine(5)-
• Rx 783006
• Tyr-ala-gly-(nme)phe-gly-ol
• Glyol
• L-Phenylalaninamide, L-tyrosyl-D-alanylglycyl-N-(2-hydroxyethyl)-Nalpha-methyl-

DAGO

CAS: 78123-71-4

Formula: C₂₆H₃₅N₅O₆

Purity: 95%

Molecular weight: 513.5860

Ref: IN-DA00G2OD

DAMGO

CAS: 78123-71-4

DAMGO

Purity: ≥98%

Molecular weight: 513.59g/mol

Ref: 54-BUP05531

DAMGO

CAS: 78123-71-4

DAMGO (DAGO) is an opioid receptor agonist with the ability to affect the locomotive activity in rodents.

Formula: C₂₆H₃₅N₅O₆

Purity: 98.83% - 99.92%

Color and Shape: Solid

Molecular weight: 513.59

Ref: TM-T4351

DAMGO

Controlled Product

CAS: 78123-71-4

Stability Hygroscopic
Applications DAMGO is an opioid receptor agonist (1,2). DAMGO can be used to investigate the analgesic mechanism of opioids. It has been shown that DAMGO can modulate the two-pore domain K(+) channels in the substantia gelatinosa neurons (3).
References (1) Talmont, F. et al.: Peptide., 55, 79 (2014) (2) Trigub, M. et al.: Bull. Exp. Biol. Med., 156, 778 (2014) (3) Cho, P. S., et al.: Korean J Physiol Pharmacol. 20, 525 (2016)

Formula: C₂₆H₃₅N₅O₆•x(C₂HF₃O₂)

Color and Shape: Neat

Molecular weight: 513.5911402

Ref: TR-D134600

DAMGO

CAS: 78123-71-4

DAMGO is an opioid drug that binds to the δ-opioid receptors in the brain's anterior cingulate cortex. It has a rate constant of 1.7 × 10/M, a high energy metabolism, and significant up-regulation of cyclase activity at doses of 10−8 M. DAMGO also inhibits guanine nucleotide-binding proteins, which are involved in immune responses and the regulation of gene expression. DAMGO may act as a pharmacological agent for infectious diseases such as HIV or bowel disease by binding to toll-like receptor 4 (TLR4) or δ receptors.

Purity: Min. 95%

Ref: 3D-BD173150