CAS 781649-09-0

Telcagepant

Description:

Telcagepant is a chemical compound that belongs to the class of small-molecule CGRP (calcitonin gene-related peptide) antagonists, primarily developed for the treatment of migraine. It is characterized by its ability to selectively inhibit the CGRP receptor, which plays a significant role in the pathophysiology of migraine headaches. The compound has a relatively complex structure, featuring multiple functional groups that contribute to its pharmacological activity. Telcagepant is known for its oral bioavailability and has been studied for its efficacy in reducing the frequency and severity of migraine attacks. Its mechanism of action involves blocking the vasodilatory effects of CGRP, thereby alleviating migraine symptoms. While it showed promise in clinical trials, further development was halted, and it has not been approved for clinical use. Overall, telcagepant represents an important step in the exploration of targeted therapies for migraine management, highlighting the role of neuropeptides in headache disorders.

Formula: C₂₆H₂₇F₅N₆O₃

InChI: InChI=1S/C26H27F5N6O3/c27-18-4-1-3-17(21(18)28)15-6-7-19(23(38)36(13-15)14-26(29,30)31)33-24(39)35-11-8-16(9-12-35)37-20-5-2-10-32-22(20)34-25(37)40/h1-5,10,15-16,19H,6-9,11-14H2,(H,33,39)(H,32,34,40)/t15-,19-/m1/s1

InChI key: InChIKey=CGDZXLJGHVKVIE-DNVCBOLYSA-N

SMILES: O=C1N(C=2C(N1)=NC=CC2)C3CCN(C(N[C@H]4C(=O)N(CC(F)(F)F)C[C@@H](CC4)C5=C(F)C(F)=CC=C5)=O)CC3

Synonyms:

• 1-Piperidinecarboxamide, N-((3R,6S)-6-(2,3-
• 1-Piperidinecarboxamide, N-[(3R,6S)-6-(2,3-difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-
• 1-yl)-
• Mk-0974
• N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-
• N-[(3R,6S)-6-(2,3-Difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-azepin-3-yl]-4-(2,3-dihydro-2-oxo-1H-imidazo[4,5-b]pyridin-1-yl)-1-piperidinecarboxamide
• Unii-D42O649All
• azepin-3-yl)-4-(2,3-dihydro-2-oxo-1H-imidazo(4,5-b)pyridin-
• difluorophenyl)hexahydro-2-oxo-1-(2,2,2-trifluoroethyl)-1H-
• imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide
• trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-
• N-(6-(2,3-difluorophenyl)-2-oxo-1-(2,2,2-
• trifluoroethyl)azepan-3-yl)-4-(2-oxo-2,3-dihydro-1H-
• imidazo(4,5-b)pyridin-1-yl)piperidine-1-carboxamide

Telcagepant

CAS: 781649-09-0

Telcagepant

Purity: ≥98%

Molecular weight: 566.52g/mol

Ref: 54-BUP21781

Telcagepant

CAS: 781649-09-0

Telcagepant (MK-0974) is an oral calcitonin gene-related peptide receptor (CGRP) antagonist that blocks CGRP receptors, migraines and for pain relief.

Formula: C₂₆H₂₇F₅N₆O₃

Purity: 98.98% - 98.98%

Color and Shape: Solid

Molecular weight: 566.52

Ref: TM-T16093

MK 0974

CAS: 781649-09-0

Antagonist of CGRP receptor

Formula: C₂₆H₂₇F₅N₆O₃

Purity: Min. 95%

Molecular weight: 566.52 g/mol

Ref: 3D-FD74910