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CAS 78186-34-2

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Bisantrene

Description:
Bisantrene is an anthracene-derived compound that belongs to the class of antitumor agents, specifically categorized as an anthracycline analog. It is primarily recognized for its potential use in cancer therapy, particularly in treating various types of leukemia and solid tumors. Bisantrene exhibits a unique mechanism of action, primarily through intercalation into DNA, which disrupts the replication process and ultimately leads to cell death. The compound is characterized by its ability to form stable complexes with DNA, thereby inhibiting topoisomerase II, an essential enzyme for DNA unwinding during replication. Bisantrene is typically administered intravenously and has been studied for its efficacy and safety profile in clinical settings. Its chemical structure contributes to its pharmacological properties, including its lipophilicity and ability to penetrate cellular membranes. However, like many chemotherapeutic agents, it may also be associated with side effects, necessitating careful monitoring during treatment. Overall, bisantrene represents a significant area of research in the development of targeted cancer therapies.
Formula:C22H22N8
InChI:InChI=1S/C22H22N8/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30)
InChI key:InChIKey=NJSMWLQOCQIOPE-UHFFFAOYSA-N
SMILES:C(=NNC=1NCCN1)C=2C3=C(C(C=NNC=4NCCN4)=C5C2C=CC=C5)C=CC=C3
Synonyms:
  • 2,2'-{anthracene-9,10-diylbis[(E)methylylidene(2E)hydrazin-1-yl-2-ylidene]}bis(4,5-dihydro-1H-imidazole)
  • 2,2'-{anthracene-9,10-diylbis[(Z)methylylidene(2Z)hydrazin-1-yl-2-ylidene]}bis(4,5-dihydro-1H-imidazole)
  • 9,10-Anthracenedicarboxaldehyde, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
  • 9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
  • 9,10-anthracenedicarboxaldehyde, bis[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
  • Bisantrene
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Found 5 products.