CAS 78186-34-2

Bisantrene

Description:

Bisantrene is an anthracene-derived compound that belongs to the class of antitumor agents, specifically categorized as an anthracycline analog. It is primarily recognized for its potential use in cancer therapy, particularly in treating various types of leukemia and solid tumors. Bisantrene exhibits a unique mechanism of action, primarily through intercalation into DNA, which disrupts the replication process and ultimately leads to cell death. The compound is characterized by its ability to form stable complexes with DNA, thereby inhibiting topoisomerase II, an essential enzyme for DNA unwinding during replication. Bisantrene is typically administered intravenously and has been studied for its efficacy and safety profile in clinical settings. Its chemical structure contributes to its pharmacological properties, including its lipophilicity and ability to penetrate cellular membranes. However, like many chemotherapeutic agents, it may also be associated with side effects, necessitating careful monitoring during treatment. Overall, bisantrene represents a significant area of research in the development of targeted cancer therapies.

Formula: C₂₂H₂₂N₈

InChI: InChI=1S/C22H22N8/c1-2-6-16-15(5-1)19(13-27-29-21-23-9-10-24-21)17-7-3-4-8-18(17)20(16)14-28-30-22-25-11-12-26-22/h1-8,13-14H,9-12H2,(H2,23,24,29)(H2,25,26,30)

InChI key: InChIKey=NJSMWLQOCQIOPE-UHFFFAOYSA-N

SMILES: C(=NNC=1NCCN1)C=2C3=C(C(C=NNC=4NCCN4)=C5C2C=CC=C5)C=CC=C3

Synonyms:

• 2,2'-{anthracene-9,10-diylbis[(E)methylylidene(2E)hydrazin-1-yl-2-ylidene]}bis(4,5-dihydro-1H-imidazole)
• 2,2'-{anthracene-9,10-diylbis[(Z)methylylidene(2Z)hydrazin-1-yl-2-ylidene]}bis(4,5-dihydro-1H-imidazole)
• 9,10-Anthracenedicarboxaldehyde, 9,10-bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
• 9,10-Anthracenedicarboxaldehyde, bis[(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
• 9,10-anthracenedicarboxaldehyde, bis[2-(4,5-dihydro-1H-imidazol-2-yl)hydrazone]
• Bisantrene

Bisantrene

CAS: 78186-34-2

Formula: C₂₂H₂₂N₈

Purity: %

Color and Shape: Solid

Molecular weight: 398.4637

Ref: IN-DA00G2FI

9,10-Bis(2-(4,5-Dihydro-1H-Imidazol-2-Yl)Hydrazono)Methyl)Anthracene

CAS: 78186-34-2

9,10-Bis(2-(4,5-Dihydro-1H-Imidazol-2-Yl)Hydrazono)Methyl)Anthracene

Purity: 95%

Molecular weight: 398.46g/mol

Ref: 54-OR1023881

Bisantrene

CAS: 78186-34-2

Bisantrene

Purity: ≥95%

Molecular weight: 398.46g/mol

Ref: 54-BUP13205

Bisantrene

CAS: 78186-34-2

Formula: C₂₂H₂₂N₈·2HCl

Molecular weight: 471.39

Ref: 7W-GP2986

Bisantrene

CAS: 78186-34-2

Bisantrene, an anthracene derivative, targets DNA causing breaks and replication inhibition; it's like doxorubicin minus the cardiotoxicity.

Formula: C₂₂H₂₂N₈

Purity: 96.07% - 98.57%

Color and Shape: Solid

Molecular weight: 398.46

Ref: TM-T4047