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CAS 78273-80-0

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Roxatidine

Description:
Roxatidine is a histamine H2-receptor antagonist primarily used to reduce gastric acid secretion and treat conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). It works by competitively inhibiting the action of histamine at the H2 receptors located on the parietal cells of the stomach lining, thereby decreasing the production of stomach acid. Roxatidine is characterized by its relatively long duration of action compared to some other H2 antagonists, which allows for less frequent dosing. The substance is typically administered orally and is well-absorbed in the gastrointestinal tract. Roxatidine has a favorable safety profile, with common side effects including headache, dizziness, and gastrointestinal disturbances. It is important to note that, like other H2 antagonists, it may interact with certain medications and should be used cautiously in patients with renal impairment. Overall, Roxatidine represents an effective option in the management of acid-related disorders, contributing to improved patient outcomes in gastrointestinal health.
Formula:C17H26N2O3
InChI:InChI=1S/C17H26N2O3/c20-14-17(21)18-8-5-11-22-16-7-4-6-15(12-16)13-19-9-2-1-3-10-19/h4,6-7,12,20H,1-3,5,8-11,13-14H2,(H,18,21)
InChI key:InChIKey=BCCREUFCSIMJFS-UHFFFAOYSA-N
SMILES:C(C1=CC(OCCCNC(CO)=O)=CC=C1)N2CCCCC2
Synonyms:
  • 2-Hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide
  • 2-hydroxy-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide
  • 2-hydroxy-N-{3-[3-(piperidin-1-ylmethyl)phenoxy]propyl}acetamide hydrochloride (1:1)
  • Acetamide, 2-hydroxy-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-
  • N-{3-[3-(1-Piperidinylmethyl)Phenoxy]Propyl}Hydroxyacetamide
  • Roxatidine
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Found 3 products.