CAS 78281-72-8
:Nepafenac
Description:
Nepafenac is a non-steroidal anti-inflammatory drug (NSAID) primarily used in ophthalmology for the treatment of pain and inflammation associated with cataract surgery. It is classified as a prodrug, which means it is converted into its active form, amfenac, after being administered. Nepafenac is characterized by its ability to inhibit cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins, which are mediators of inflammation and pain. The substance is typically formulated as an eye drop solution, allowing for localized treatment with minimal systemic absorption. Its chemical structure includes a phenylacetic acid moiety, contributing to its pharmacological activity. Nepafenac is known for its relatively low side effect profile compared to other NSAIDs, making it a preferred choice for postoperative ocular inflammation. Additionally, it has a favorable pharmacokinetic profile, allowing for once-daily dosing in many cases. Overall, nepafenac represents an important therapeutic option in managing ocular inflammation and pain.
Formula:C15H14N2O2
InChI:InChI=1S/C15H14N2O2/c16-13(18)9-11-7-4-8-12(14(11)17)15(19)10-5-2-1-3-6-10/h1-8H,9,17H2,(H2,16,18)
InChI key:InChIKey=QEFAQIPZVLVERP-UHFFFAOYSA-N
SMILES:C(=O)(C1=C(N)C(CC(N)=O)=CC=C1)C2=CC=CC=C2
Synonyms:- 2-(2-Amino-3-Benzoylphenyl)Acetamide
- 2-Amino-3-benzoylbenzeneacetamide
- Ahr 9434
- Al 6515
- Benzeneacetamide, 2-amino-3-benzoyl-
- Ilevro
- Nevanac
- Nepafenac
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Found 11 products.
Nepafenac
CAS:Formula:C15H14N2O2Purity:>98.0%(T)(HPLC)Color and Shape:Light yellow to Yellow to Orange powder to crystalMolecular weight:254.29Nepafenac
CAS:Aromatic cyclic amides (including cyclic carbamates) and their derivatives; salts thereofFormula:C15H14N2O2Color and Shape:Yellow PowderMolecular weight:254.10553Nepafenac
CAS:<p>Nepafenac (AHR 9434) is an NSAID that acts as a cyclooxygenase inhibitor.</p>Formula:C15H14N2O2Purity:98.94% - 99.43%Color and Shape:SolidMolecular weight:254.28Nepafenac
CAS:Formula:C15H14N2O2Purity:≥ 98.0% (dried basis)Color and Shape:Off-white, pale yellow or yellow powderMolecular weight:254.28Nepafenac
CAS:<p>Applications A non-steroidal anti-inflammatory with analgesic activity; selective COX-2 inhibitor. Prodrug of Amfenac.<br> Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package<br>References Walsh, D.A., et al.: J. Med. Chem., 33, 2296 (1990), Gamache, D.A., et al.: Inflammation, 24, 357 (2000), Lindstrom, R., et al.: Curr. Med. Res. Opin., 22, 397 (2006),<br></p>Formula:C15H14N2O2Color and Shape:NeatMolecular weight:254.282-Amino-3-benzoylbenzeneacetamide
CAS:<p>2-Amino-3-benzoylbenzeneacetamide is an ophthalmic drug that has significant cytotoxicity. It is used to treat inflammation of the retina and macula, as well as other diseases of the eye such as uveitis. 2-Amino-3-benzoylbenzeneacetamide is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits prostaglandin synthesis by blocking cyclooxygenase. This agent has been shown to be effective in reducing pain and inflammation in animal models, but there are no studies on its side effects or analytical methods for detection. There are also no studies on the effectiveness of this drug for treating uveitis.</p>Formula:C15H14N2O2Purity:Min. 95%Color and Shape:PowderMolecular weight:254.28 g/mol
