CAS 78287-27-1
:7-Ethylcamptothecin
Description:
7-Ethylcamptothecin is a synthetic derivative of camptothecin, a compound originally isolated from the bark of the Chinese tree Camptotheca acuminata. This substance is characterized by its unique structure, which includes a pentacyclic ring system that contributes to its biological activity. It exhibits potent antitumor properties, primarily through its mechanism of action as a topoisomerase I inhibitor, which interferes with DNA replication and transcription, leading to cell death in rapidly dividing cancer cells. 7-Ethylcamptothecin is known for its improved solubility and stability compared to its parent compound, making it a subject of interest in cancer research and drug development. The compound is typically studied in various formulations for its efficacy against different types of cancers, including colorectal and ovarian cancers. However, like many chemotherapeutic agents, it may also present challenges such as toxicity and side effects, necessitating careful consideration in clinical applications. Overall, 7-Ethylcamptothecin represents a significant advancement in the field of oncology, with ongoing research aimed at optimizing its therapeutic potential.
Formula:C22H20N2O4
InChI:InChI=1/C22H20N2O4/c1-3-12-13-7-5-6-8-17(13)23-19-14(12)10-24-18(19)9-16-15(20(24)25)11-28-21(26)22(16,27)4-2/h5-9,27H,3-4,10-11H2,1-2H3/t22-/m0/s1
InChI key:InChIKey=MYQKIWCVEPUPIL-QFIPXVFZSA-N
SMILES:O=C1N2C(C=3C(C2)=C(CC)C=4C(N3)=CC=CC4)=CC5=C1COC(=O)[C@@]5(CC)O
Synonyms:- (4S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (4S)-4,11-diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione
- (S)-4,11-Diethyl-4-hydroxy-1H-pyrano(3',4':6,7)indolizino(1,2-b)quinoline-3,14(4H,12H)-dione
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-, (4S)-
- 1H-Pyrano[3′,4′:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione, 4,11-diethyl-4-hydroxy-, (S)-
- 7-Ethyl Camptothecin
- 7-Ethyl-20(S)-camptothecin
- Sn 22
- 7-Ethylcamptothecin
- 7-ETHYL-CAMPTOTHECIN,HPLC 99%
- (4S)-4,11-Diethyl-4-hydroxy-3,4,12,14-tetrahydro-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14-dione
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 12 products.
7-Ethylcamptothecin
CAS:Formula:C22H20N2O4Purity:>98.0%(T)(HPLC)Color and Shape:Light orange to Yellow to Green powder to crystalMolecular weight:376.41Irinotecan Related Compound E ((S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione)
CAS:<p>Vegetable alkaloids, natural or reproduced by synthesis, their salts and other derivatives, nesoi</p>Formula:C22H20N2O4Color and Shape:Light Brown PowderMolecular weight:376.14231Irinotecan EP Impurity F (7-Ethyl Camptothecin)
CAS:Formula:C22H20N2O4Color and Shape:Yellow SolidMolecular weight:376.417-Ethylcamptothecin
CAS:<p>1.</p>Formula:C22H20N2O4Purity:99.08%Color and Shape:Light Pink SolidMolecular weight:376.417-Ethyl Camptothecin
CAS:<p>Impurity Irinotecan USP Related Compound E<br>Applications An anticancer drug, showed strong activity against various murine tumors. A Camptothecin (CPT) derivative as antineoplastic agent against drug-resistant tumors. Irinotecan USP Related Compound E.<br>References Brangi, M., et al.: Cancer Res., 59 5938 (1999), Miyake, K., et al.: Cancer Res., 59, 8 (1999) , Bom, D., et al.: J. Med. Chem., 43, 3970 (2000) , Gamcsik, M., et al.: Mol. Cancer Ther., 1, 11 (2001).<br></p>Formula:C22H20N2O4Color and Shape:Light YellowMolecular weight:376.41
![(S)-4,11-Diethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione (7-Et…](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2F86%2Fthumb%2FMM1157.05-0025.jpg&w=3840&q=75)
