CAS 78366-44-6

dihydrocompactin

Description:

Dihydrocompactin, with the CAS number 78366-44-6, is a chemical compound that belongs to the class of statins, which are primarily used for their cholesterol-lowering properties. It is a derivative of compactin, a natural product originally isolated from the fungus Penicillium citrinum. Dihydrocompactin exhibits a structure characterized by a lactone ring and a hydroxy group, which contribute to its biological activity. The compound functions by inhibiting HMG-CoA reductase, an enzyme crucial in the cholesterol biosynthesis pathway, thereby reducing the levels of low-density lipoprotein (LDL) cholesterol in the bloodstream. In addition to its lipid-lowering effects, dihydrocompactin may possess other pharmacological properties, including potential anti-inflammatory and antioxidant effects. Its solubility and stability can vary depending on the formulation and conditions, which are important factors for its therapeutic application. As with other statins, the use of dihydrocompactin may be associated with side effects, necessitating careful monitoring in clinical settings.

Formula: C₂₃H₃₆O₅

InChI: InChI=1/C23H36O5/c1-4-14(2)23(26)28-20-7-5-6-16-9-8-15(3)19(22(16)20)11-10-18-12-17(24)13-21(25)27-18/h8-9,14-20,22,24H,4-7,10-13H2,1-3H3/t14-,15?,16+,17+,18+,19?,20-,22?/m0/s1

Synonyms:

• dihydrocompactin
• Butanoic acid, 2-methyl-, (1S,4aR,7S,8S,8aS)-1,2,3,4,4a,7,8,8a-octahydro-7-methyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2S)-

Dihydrocompactin

CAS: 78366-44-6

Dihydrocompactin is an antifungal metabolite derived from Penicillium citrinum and acts as an inhibitor of 3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMG-CoA reductase).

Formula: C₂₃H₃₆O₅

Color and Shape: Solid

Molecular weight: 392.529

Ref: TM-TN9920