CAS 78432-77-6

10-Deacetyltaxol

Description:

10-Deacetyltaxol, with the CAS number 78432-77-6, is a derivative of the natural product taxol, which is known for its anticancer properties. This compound is characterized by the absence of an acetyl group at the C10 position, which distinguishes it from taxol. It exhibits a complex polycyclic structure typical of taxanes, featuring a taxane core that contributes to its biological activity. 10-Deacetyltaxol is primarily recognized for its ability to stabilize microtubules, thereby inhibiting cell division, which is a crucial mechanism in cancer treatment. The compound is often studied for its potential therapeutic applications and may exhibit varying degrees of cytotoxicity against different cancer cell lines. Additionally, its solubility and stability in biological systems can influence its efficacy as a therapeutic agent. Overall, 10-Deacetyltaxol represents an important compound in the field of medicinal chemistry, particularly in the development of chemotherapeutic agents.

Formula: C₄₅H₄₉NO₁₃

InChI: InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30-,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

InChI key: InChIKey=TYLVGQKNNUHXIP-MHHARFCSSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Synonyms:

• (2alpha,5beta,7beta,10beta,13alpha)-4-(acetyloxy)-13-{[(2R,3S)-3-(benzoylamino)-2-hydroxy-3-phenylpropanoyl]oxy}-1,7,10-trihydroxy-9-oxo-5,20-epoxytax-11-en-2-yl benzoate
• 10-Deacetylpaclitaxel
• 10-Deacetyltaxol
• 10-Deacetyltaxol A
• 10-Desacetylpaclitaxel
• 10-Desacetyltaxol
• 10-O-Deacetyltaxol
• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-Epi-10-deacetyl paclitaxel
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, 12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, [2aR-[2aα,4β,4aβ,6β,9α(αR*,βS*),11α,12α,12aα,12bα]]-

Paclitaxel EP Impurity G (10-Desacetyl Paclitaxel)

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Color and Shape: Pink Solid

Molecular weight: 811.88

Ref: 4Z-P-286

10-Deacetyltaxol

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 811.88

Ref: 7W-GY7900

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol

Purity: ≥90%

Molecular weight: 811.87g/mol

Ref: 54-BUP00167

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol and cephalomannine have cytotoxicity in human glial and neuroblastoma cell-lines, the tumors of the central and peripheral nervous system are sensitive to 10-deacetyltaxol and cephalomannine and these drugs are less toxic than taxol but remain within a therapeutic range.

Formula: C₄₅H₄₉NO₁₃

Purity: 95%~99%

Molecular weight: 811.881

Ref: BP-BP0012

10-Deacetyltaxol

CAS: 78432-77-6

10-Deacetyltaxol (10-DAT) is extracted from Taxus brevifolia barks.

Formula: C₄₅H₄₉NO₁₃

Purity: 94.63% - 99.93%

Color and Shape: Solid

Molecular weight: 811.87

Ref: TM-T5165

10-Deacetyltaxol

CAS: 78432-77-6

Molecular weight: 811.881

Ref: 10-F986787

10-Desacetyl Paclitaxel

CAS: 78432-77-6

Impurity Paclitaxel - impurity G
Applications A semi-synthetic precursor of Paclitaxel. Paclitaxel - impurity G.

Formula: C₄₅H₄₉NO₁₃

Color and Shape: White To Off-White

Molecular weight: 811.87

Ref: TR-D288710

10-Desacetyl paclitaxel

CAS: 78432-77-6

10-Desacetyl paclitaxel is a form of paclitaxel that has been modified chemically. It is soluble in water and can be injected intravenously. 10-Desacetyl paclitaxel is used to treat inflammatory diseases, such as rheumatoid arthritis and psoriasis. This drug binds to the hydroxyl groups on the surface of the bacterial cell wall and prevents the formation of covalent linkages with polysaccharides, which leads to its increased patency in bacterial cells. 10-Desacetyl paclitaxel has also been shown to inhibit the activity of certain enzymes that are involved in synthesis of DNA, RNA, and proteins. This inhibition results in cell death by apoptosis or necrosis. The increase in viability after treatment with 10-desacetyl paclitaxel was observed for both gram-positive bacteria (e.g., Bacillus subtilis) and gram-negative bacteria (e.g., Escher

Formula: C₄₅H₄₉NO₁₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 811.87 g/mol

Ref: 3D-FD21126

Paclitaxel EP Impurity G

CAS: 78432-77-6

Formula: C₄₅H₄₉NO₁₃

Molecular weight: 811.88

Ref: ST-EA-CP-P36007