CAS 78439-06-2

Ceftazidime pentahydrate

Description:

Ceftazidime pentahydrate is a broad-spectrum cephalosporin antibiotic used primarily in the treatment of infections caused by Gram-negative bacteria. It is characterized by its ability to inhibit bacterial cell wall synthesis, making it effective against a variety of pathogens, including Pseudomonas aeruginosa. The pentahydrate form indicates that the compound contains five molecules of water, which can influence its solubility and stability. Ceftazidime is typically administered via injection and is often used in hospital settings for serious infections, including those in immunocompromised patients. Its chemical structure features a beta-lactam ring, which is essential for its antibacterial activity. The compound is generally well-tolerated, but like all antibiotics, it can cause side effects, including allergic reactions and gastrointestinal disturbances. Due to the emergence of antibiotic resistance, its use is often guided by susceptibility testing to ensure effectiveness against specific bacterial strains.

Formula: C₂₂H₂₂N₆O₇S₂·5H₂O

InChI: InChI=1S/C22H22N6O7S2.5H2O/c1-22(2,20(33)34)35-26-13(12-10-37-21(23)24-12)16(29)25-14-17(30)28-15(19(31)32)11(9-36-18(14)28)8-27-6-4-3-5-7-27;;;;;/h3-7,10,14,18H,8-9H2,1-2H3,(H4-,23,24,25,29,31,32,33,34);5*1H2/b26-13-;;;;;/t14-,18-;;;;;/m1...../s1

InChI key: InChIKey=NMVPEQXCMGEDNH-TZVUEUGBSA-N

SMILES: C([O-])(=O)C=1N2[C@@]([C@H](NC(/C(=N\OC(C(O)=O)(C)C)/C3=CSC(N)=N3)=O)C2=O)(SCC1C[N+]=4C=CC=CC4)[H].O

Synonyms:

• (6R,7R)-7-({(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• (6R,7R)-7-({(2E)-2-(2-amino-1,3-thiazol-4-yl)-2-[(1-carboxy-1-methylethoxy)imino]acetyl}amino)-8-oxo-3-(pyridinium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate pentahydrate
• Cefidime
• Ceftadizim
• Glazidim
• Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, hydrate (1:5)
• Pyridinium, 1-[[(6R,7R)-7-[[(2Z)-(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, pentahydrate
• Pyridinium, 1-[[7-[[(2-amino-4-thiazolyl)[(1-carboxy-1-methylethoxy)imino]acetyl]amino]-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-, inner salt, pentahydrate, [6R-[6α,7β(Z)]]-
• Starcef 1
• pentahydrate (6R,7R)-7-[[(2Z)-2-(2-Amino-1,3-thiazol-4-yl)-2-(1-hydroxy-2-methyl-1-oxopropan-2-yl)oxyiminoacetyl]amino]-8-oxo-3-(pyridin-1-ium-1-ylmethyl)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate
• Ceftazidime pentahydrate

Ceftazidime pentahydrate, 95%

CAS: 78439-06-2

Ceftazidime pentahydrate is an antibacterial agent. It is used especially for Pseudomonas and other gram-negative infections in debilitated patients. It is used in the treatment of patients with infections caused by susceptible strains of organisms in the following diseases: lower respiratory tract

Formula: C₂₂H₃₂N₆O₁₂S₂

Purity: 95%

Color and Shape: Powder or crystals or crystalline powder, White to off-white

Molecular weight: 636.65

Ref: 02-J66460

CEFTAZIDIME CRS

CAS: 78439-06-2

CEFTAZIDIME CRS

Ref: 41-C0690500

Ceftazidime Pentahydrate

CAS: 78439-06-2

Antibiotics nesoi

Formula: C₂₂H₂₂N₆O₇S₂·5H₂O

Color and Shape: White Cream Crystalline Powder

Molecular weight: 636.15196

Ref: 45-1098130

Ceftazidime pentahydrate

CAS: 78439-06-2

Formula: C₂₂H₃₂N₆O₁₂S₂

Purity: %

Color and Shape: Solid

Molecular weight: 636.6525

Ref: IN-DA005B3Q

Ceftazidime hydrate, contains approx. 10% sodium carbonate

CAS: 78439-06-2

Formula: C₂₂H₂₂N₆O₇S₂·xH₂O

Purity: 95.0 - 102.0 % (on dried basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 546.58

Ref: 7W-GA1898

Ceftazidime Pentahydrate

CAS: 78439-06-2

Ceftazidime Pentahydrate

Purity: ≥98%

Molecular weight: 636.65g/mol

Ref: 54-BUP18349

Ceftazidime hydrate

CAS: 78439-06-2

Formula: C₂₂H₂₂N₆O₇S₂·xH₂O

Purity: 95.0 - 102.0 % (anhydrous basis)

Color and Shape: White to off-white crystalline powder

Molecular weight: 546.58 (anhydrous)

Ref: 7W-GA6002

Ceftazidime Pentahydrate

CAS: 78439-06-2

Ceftazidime Pentahydrate

Purity: 95%

Molecular weight: 636.65g/mol

Ref: 54-OR1024612

Ceftazidime hydrate, USP grade

CAS: 78439-06-2

Formula: C₂₂H₂₂N₆O₇S₂·xH₂O

Purity: (HPLC) 95.0 - 102.0 % (dried basis)

Color and Shape: White to off-white powder or crystals

Molecular weight: 546.58 (anhydrous)

Ref: 7W-GP7286

Ceftazidime RS

CAS: 78439-06-2

Color and Shape: White To Light Yellow-White Solid Crystalline Powder

Ref: 2K-7000560021

Ceftazidime Pentahydrate

CAS: 78439-06-2

Ceftazidime Pentahydrate is a cephalosporin antibiotic with activity against gram-negative bacilli and may be used to study infectious diseases.

Formula: C₂₂H₃₂N₆O₁₂S₂

Purity: 99.39%

Color and Shape: White To Cream-Colored Crystalline Powder

Molecular weight: 636.65

Ref: TM-T8261

Ceftazidime Pentahydrate(Contain 1 equivalent of Na2CO3 as stabilizer)

CAS: 78439-06-2

Applications Third generation cephalosporin antibiotic. Antibacterial.
References Brodie, A., et al.: Antimicrob. Agents Chemother., 17, 876 (1980), Richards, D.M., et al.: Drugs, 29, 105 (1985), Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 19, 95 (1990),

Formula: C₂₂H₂₂N₆O₇S₂·5H₂O

Color and Shape: White

Molecular weight: 636.65

Ref: TR-C244100

Ceftazidime-d5 (>90%)

Controlled Product

CAS: 78439-06-2

Stability Light, Moisture and temperature sensitive
Applications Third generation cephalosporin antibiotic. Antibacterial.
References Brodie, A., et al.: Antimicrob. Agents Chemother., 17, 876 (1980), Richards, D.M., et al.: Drugs, 29, 105 (1985), Abounassif, M.A., et al.: Anal. Profiles Drug Subs., 19, 95 (1990),

Formula: C₂₂H₁₇D₅N₆O₇S₂

Purity: 90%

Color and Shape: Neat

Molecular weight: 551.61

Ref: TR-C244102

Ceftazidime impurity B

CAS: 78439-06-2

Ceftazidime impurity B is a ceftazidime impurity that is found in the drug Ceftazidime. Ceftazidime is an antibiotic that belongs to the group of cephalosporin antibiotics and inhibits bacterial growth by inhibiting cell wall synthesis. Ceftazidime impurity B has been shown to be toxic to gram-positive bacteria, such as Enterococcus faecium and Staphylococcus aureus, but not to gram-negative bacteria, such as Escherichia coli. In addition, it has been shown to have no effect on the IL-2 receptor of T cells or the binding of penicillin-binding protein. It has also been shown to be safe for injection into mice and rats in toxicity studies.

Formula: C₂₂H₂₂N₆O₇S₂

Purity: Min. 95%

Molecular weight: 546.58 g/mol

Ref: 3D-IC63717

Ceftazidime pentahydrate

CAS: 78439-06-2

A broad-spectrum antibiotic of cephalosporin class, which inhibits bacterial cell wall synthesis by targeting the penicillin-binding protein, involved in peptidoglycan synthesis. This third-generation cephalosporin is very active against Pseudomonas species and can also be used to treat bacterial meningitis as it penetrates in the cerebrospinal fluid.

Formula: C₂₂H₃₂N₆O₁₂S₂

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 636.65 g/mol

Ref: 3D-AC19871