CAS 78454-17-8

7-epi-10-Deacetyltaxol

Description:

7-epi-10-Deacetyltaxol, with the CAS number 78454-17-8, is a semi-synthetic derivative of the natural product taxol, which is known for its anticancer properties. This compound features a complex polycyclic structure characteristic of taxanes, including a taxane core with specific functional groups that contribute to its biological activity. It exhibits a high degree of stereochemistry, which is crucial for its interaction with biological targets, particularly in inhibiting cell division by stabilizing microtubules. The compound is typically studied for its potential therapeutic applications in oncology, as it may exhibit cytotoxic effects against various cancer cell lines. Additionally, 7-epi-10-Deacetyltaxol may possess different pharmacokinetic and pharmacodynamic properties compared to its parent compound, influencing its efficacy and safety profile. Its solubility, stability, and formulation characteristics are also important for its development as a pharmaceutical agent. Overall, this compound represents a significant area of research in the field of medicinal chemistry and cancer treatment.

Formula: C₄₅H₄₉NO₁₃

InChI: InChI=1S/C45H49NO13/c1-24-29(57-41(54)35(50)33(26-15-9-6-10-16-26)46-39(52)27-17-11-7-12-18-27)22-45(55)38(58-40(53)28-19-13-8-14-20-28)36-43(5,37(51)34(49)32(24)42(45,3)4)30(48)21-31-44(36,23-56-31)59-25(2)47/h6-20,29-31,33-36,38,48-50,55H,21-23H2,1-5H3,(H,46,52)/t29-,30+,31+,33-,34+,35+,36-,38-,43+,44-,45+/m0/s1

InChI key: InChIKey=TYLVGQKNNUHXIP-DIYBZAJCSA-N

SMILES: O(C(C)=O)[C@]12[C@]3([C@H](OC(=O)C4=CC=CC=C4)[C@@]5(O)C(C)(C)C([C@@H](O)C(=O)[C@]3(C)[C@H](O)C[C@]1(OC2)[H])=C(C)[C@@H](OC([C@@H]([C@@H](NC(=O)C6=CC=CC=C6)C7=CC=CC=C7)O)=O)C5)[H]

Synonyms:

• 7,11-Methano-1H-cyclodeca[3,4]benz[1,2-b]oxete, benzenepropanoic acid deriv.
• 7-EPI-10-DEACETYL-TAXOL
• Benzenepropanoic acid, β-(benzoylamino)-α-hydroxy-, (2aR,4R,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]benz[1,2-b]oxet-9-yl ester, (αR,βS)-
• 7-Epi-10-deacetyltaxol
• 7-epi-10-Deacetyltaxol
• 2'-epi-3'-epi-10-Deacetyltaxol
• 10-Deacetyl-7-epitaxol

Paclitaxel Related Compound B (10-deacetyl-7-epipaclitaxel)

CAS: 78454-17-8

Aromatic heterocyclic compounds with oxygen hetero-atom(s) only, nesoi

Formula: C₄₅H₄₉O₁₃N

Color and Shape: White Off-White Powder

Molecular weight: 811.32039

Ref: 45-1491354

7-Epi-10-deacetyltaxol

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 811.8695

Ref: IN-DA00G4XF

7-epi-10-Deacetyltaxol

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Purity: ≥ 98.0%

Color and Shape: White to yellow solid

Molecular weight: 811.87

Ref: 7W-GP6698

7-Epi 10-desacetyl paclitaxel

CAS: 78454-17-8

7-Epi 10-desacetyl paclitaxel

Purity: ≥98%

Molecular weight: 811.87g/mol

Ref: 54-BUP21038

Paclitaxel EP Impurity H (Paclitaxel USP Related Compound B, 7-epi-10-Desacetyl-Paclitaxel)

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Color and Shape: White To Off-White Solid

Molecular weight: 811.88

Ref: 4Z-P-2814

10-O-Deacetyl-7-epi-paclitaxel

CAS: 78454-17-8

Color and Shape: Neat

Ref: 86-MM1489.01

7-Epi 10-desacetyl paclitaxel

CAS: 78454-17-8

Purity: 98%

Molecular weight: 811.320390628

Ref: 10-F987960

10-Deacetyl-7-epipaclitaxel

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Purity: 95%~99%

Molecular weight: 811.881

Ref: BP-SBP03777

7-Epi 10-desacetyl paclitaxel

CAS: 78454-17-8

7-Epi 10-desacetyl paclitaxel (10-Deacetyl-7-epipaclitaxel) shows IC50 values of 0.085 nM, against HeLa cells.

Formula: C₄₅H₄₉NO₁₃

Purity: 98.05% - 99.01%

Color and Shape: Solid

Molecular weight: 811.87

Ref: TM-T5738

7-Epi 10-Desacetyl Paclitaxel

Controlled Product

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Color and Shape: Neat

Molecular weight: 811.87

Ref: TR-E583500

Paclitaxel EP Impurity H

CAS: 78454-17-8

Formula: C₄₅H₄₉NO₁₃

Molecular weight: 811.88

Ref: ST-EA-CP-P36008

7-Epi 10-desacetyl paclitaxel

CAS: 78454-17-8

7-Epi 10-desacetyl paclitaxel is a prodrug of paclitaxel. It has a similar mechanism of action to paclitaxel, and is used as a chemotherapeutic agent for the treatment of cancer. 7-Epi 10-desacetyl paclitaxel has shown potent apoptotic activity in cell culture, as well as in animal models. This drug is prepared by high performance liquid chromatography and is used to treat cancer. The drug may also be activated by an enzyme called adenosine diphosphate ribose (ADPR), which forms from ATP during cellular metabolism. 7-Epi 10-desacetyl paclitaxel may also have anticancer effects on cervical cancer cells due to its ability to inhibit the synthesis of DNA and RNA.

Formula: C₄₅H₄₉NO₁₃

Purity: Min. 95%

Color and Shape: White Powder

Molecular weight: 811.87 g/mol

Ref: 3D-IE22703