CAS 78613-35-1

Amorolfine

Description:

Amorolfine is an antifungal agent primarily used in the treatment of onychomycosis, a fungal infection of the nails. It belongs to the morpholine class of compounds and exhibits a broad spectrum of antifungal activity against dermatophytes, yeasts, and molds. The mechanism of action involves the inhibition of fungal sterol biosynthesis, specifically targeting the enzyme Δ14-reductase, which is crucial for the synthesis of ergosterol, an essential component of fungal cell membranes. Amorolfine is typically formulated as a nail lacquer, allowing for localized treatment with minimal systemic absorption. Its efficacy is enhanced by its ability to penetrate the nail plate and reach the site of infection. The substance is generally well-tolerated, with few side effects, although some users may experience local irritation or allergic reactions. Amorolfine is often preferred for its convenience and effectiveness, making it a popular choice in dermatological practice for managing nail fungal infections.

Formula: C₂₁H₃₅NO

InChI: InChI=1/C21H35NO/c1-7-21(5,6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22/h8-11,16-18H,7,12-15H2,1-6H3/t16?,17-,18+

InChI key: InChIKey=MQHLMHIZUIDKOO-AYHJJNSGNA-N

SMILES: C(C(CN1C[C@H](C)O[C@H](C)C1)C)C2=CC=C(C(CC)(C)C)C=C2

Synonyms:

• Fradafi
• Fradafiban
• Loceryl
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-rel-
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, cis-
• Ro 14-4767
• Ro 14-4767/000
• Sylimarin
• rel-(2R,6S)-4-[3-[4-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethylmorpholine
• Amorolfine
• (+/-)-cis-2,6-dimethyl-4-[2-methyl-3-(p-tert-pentylphenyl)propyl]morpholine
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-
• 4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2β,6β-dimethylmorpholine
• cis-4-[3-3[4-(1，1-Dimethylpropyl)phenyl]-2-methypropyl]-2，6-dimethylmor-pholine
• Morpholine, 4-[3-[4-(1,1-dimethylpropyl)phenyl]-2-methylpropyl]-2,6-dimethyl-, (2R,6S)-
• 4-(3-(4-(1,1-Dimethylpropyl)phenyl)-2-methylpropyl)-2,6-dimethylmorpholine
• amorolfin
• Ro-l4-4767/000
• 4-[3-[p-(1,1-Dimethylpropyl)phenyl]-2-methylpropyl]-2α,6α-dimethylmorpholine

Amorolfine

CAS: 78613-35-1

Applications Amorolfine is a novel antifungal agent used in the treatment of cutaneous fungal disease.
References Rosen, T. et al.: J. Drugs Dermatol., 14, 48 (2015);

Formula: C₂₁H₃₅NO

Color and Shape: Neat

Molecular weight: 317.51

Ref: TR-A616753

Amorolfine

CAS: 78613-35-1

Amorolfine is available in the nail lacquer and can be used to treat fungal nail infections.

Formula: C₂₁H₃₅NO

Color and Shape: White To Off-White Crystalline Powder

Molecular weight: 317.517

Ref: TM-T0187L