CAS 78628-28-1

Roxatidine acetate

Description:

Roxatidine acetate is a pharmaceutical compound primarily used as an antihistamine and an antiulcer agent. It functions as a selective H2 receptor antagonist, which helps reduce gastric acid secretion, making it effective in treating conditions such as peptic ulcers and gastroesophageal reflux disease (GERD). The compound is characterized by its ability to provide symptomatic relief from acid-related disorders by blocking histamine's action on H2 receptors in the stomach lining. Roxatidine acetate is typically administered orally and is known for its relatively long duration of action compared to other H2 antagonists. It is generally well-tolerated, with a side effect profile that may include headache, dizziness, or gastrointestinal disturbances in some patients. The compound's chemical structure includes an acetate group, which contributes to its pharmacological properties. As with any medication, it is essential to use Roxatidine acetate under medical supervision to ensure safety and efficacy, particularly in patients with pre-existing health conditions or those taking other medications.

Formula: C₁₉H₂₈N₂O₄

InChI: InChI=1S/C19H28N2O4/c1-16(22)25-15-19(23)20-9-6-12-24-18-8-5-7-17(13-18)14-21-10-3-2-4-11-21/h5,7-8,13H,2-4,6,9-12,14-15H2,1H3,(H,20,23)

InChI key: InChIKey=SMTZFNFIKUPEJC-UHFFFAOYSA-N

SMILES: C(C1=CC(OCCCNC(COC(C)=O)=O)=CC=C1)N2CCCCC2

Synonyms:

• 2-(Acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]acetamide
• 2-Oxo-2-({3-[3-(Piperidin-1-Ylmethyl)Phenoxy]Propyl}Amino)Ethyl Acetate
• 3-[3-(1-Piperidylmethyl)phenoxy]propylcarbamoylmethyl acetate
• Aceroxatidine
• Acetamide, 2-(acetyloxy)-N-[3-[3-(1-piperidinylmethyl)phenoxy]propyl]-
• Pifatidine
• Roxatidine acetate
• 2-Acetoxy-N-[3-[m-(piperidinomethyl)phenoxy]propyl]acetamide
• Altat：TZU-0460
• Gastralgin：Roxit
• HOE-760
• 2-(acetyloxy)-n-(3-(3-(1-piperidinylmethyl)phenoxy)propyl)-acetamid

Roxatidine Acetate

CAS: 78628-28-1

Formula: C₁₉H₂₈N₂O₄

Molecular weight: 348.4366

Ref: IN-DA00G24Q

Roxatidine acetate

CAS: 78628-28-1

Formula: C₁₉H₂₈N₂O₄

Molecular weight: 348.44

Ref: 7W-GP8495

Roxatidine acetate

CAS: 78628-28-1

Roxatidine acetate: anti-ulcer, blocks histamine, reduces acid. Safer at lower doses.

Formula: C₁₉H₂₈N₂O₄

Purity: 98%

Color and Shape: White Or Off-White Powder

Molecular weight: 348.44

Ref: TM-T0157L

Roxatidine acetate

CAS: 78628-28-1

Roxatidine acetate is a prodrug that is metabolized to roxatidine, its active form, in the liver. Roxatidine acetate has been shown to have antioxidative properties, which may be due to its ability to inhibit the production of reactive oxygen species. It also prevents the accumulation of fatty acid in the kidneys and reduces glomerular filtration rate. Roxatidine acetate binds to integrin receptors on oral pathogens, preventing them from attaching to host tissue and causing infection. This drug has been shown to be effective against a number of oral pathogens, including Streptococcus mutans, Enterococcus faecalis, Helicobacter pylori, Lactobacillus acidophilus, and Candida albicans. Roxatidine acetate is not metabolized by cytochrome P450 enzymes or glucuronidases and does not interact with other drugs or food components.

Formula: C₁₉H₂₈N₂O₄

Purity: Min. 95%

Molecular weight: 348.4 g/mol

Ref: 3D-DDA62828