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CAS 78628-80-5

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Terbinafine hydrochloride

Description:
Terbinafine hydrochloride is an antifungal medication primarily used to treat dermatophyte infections, such as athlete's foot, ringworm, and nail fungus. It belongs to the allylamine class of antifungals and works by inhibiting the enzyme squalene epoxidase, which is crucial for the synthesis of ergosterol, an essential component of fungal cell membranes. This disruption leads to cell death and effectively clears the infection. Terbinafine hydrochloride is typically administered orally or topically, depending on the type and severity of the infection. The substance is characterized by its white to off-white crystalline powder form, with a relatively low solubility in water, which can affect its absorption and bioavailability. It has a molecular formula that reflects its complex structure, and its pharmacokinetics involve extensive hepatic metabolism. Side effects may include gastrointestinal disturbances, skin reactions, and, in rare cases, liver toxicity. Overall, terbinafine hydrochloride is a potent and widely used agent in the treatment of fungal infections, with a well-established safety profile when used as directed.
Formula:C21H26ClN
InChI:InChI=1/C21H25N/c1-21(2,3)15-8-5-9-16-22(4)17-19-13-10-12-18-11-6-7-14-20(18)19/h5-7,9-14H,16-17H2,1-4H3/b9-5+
InChI key:InChIKey=BWMISRWJRUSYEX-SZKNIZGXSA-N
SMILES:C(N(C/C=C/C#CC(C)(C)C)C)C=1C2=C(C=CC1)C=CC=C2.Cl
Synonyms:
  • (2E)-N,6,6-trimethyl-N-(naphthalen-1-ylmethyl)hept-2-en-4-yn-1-amine
  • (E)-N-(6,6-Dimethyl-2-Hepten-4-Ynyl)-N-Methyl-1-Naphthalenemethylaminehydroc
  • (E)-N-(6,6-Dimethyl-2-hepten-4-ynyl)-N-methyl-1-naphthalenemethanamine monohydrochloride
  • (E)-N-(6,6-dimethyl-2-heptene-4-alkyne)-N-methyl-l-naphthalene methylamine hydrochloride
  • 1-Naphthalenemethanamine, N-(6,6-dimethyl-2-hepten-4-ynyl)-N-methyl-, hydrochloride, (E)-
  • 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-yn-1-yl]-N-methyl-, hydrochloride (1:1)
  • 1-Naphthalenemethanamine, N-[(2E)-6,6-dimethyl-2-hepten-4-ynyl]-N-methyl-, hydrochloride
  • Bramazil
  • Bramizil
  • Lamisil
  • See more synonyms
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