CAS 78635-98-0

Thymidine, 3'-(4-oxopentanoate)

Description:

Thymidine, 3'-(4-oxopentanoate), with the CAS number 78635-98-0, is a derivative of thymidine, a nucleoside that plays a crucial role in DNA synthesis. This compound features a 4-oxopentanoate moiety attached to the 3' position of the thymidine molecule, which can influence its biochemical properties and interactions. Thymidine itself consists of a thymine base linked to a deoxyribose sugar, and the modification at the 3' position can affect its solubility, stability, and reactivity. Such derivatives are often studied for their potential applications in biochemistry and molecular biology, particularly in the context of nucleic acid research and drug development. The presence of the 4-oxopentanoate group may also impart unique characteristics, such as altered binding affinities or enhanced cellular uptake. Overall, this compound exemplifies the diverse modifications that can be made to nucleosides to explore their functional properties in various biological systems.

Formula: C₁₅H₂₀N₂O₇

3'-O-Levulinoyl-N-benzoyl-2'-deoxythymidine

Controlled Product

CAS: 78635-98-0

Applications 3'-O-Levulinoyl-N-benzoyl-2'-deoxythymidine is a protected nucleotide derivative/building block.
References Kiuru, E., et al.: Helvetica Chimica Acta, 96, 1997-2008 (2013);

Formula: C₁₅H₂₀N₂O₇

Color and Shape: Neat

Molecular weight: 340.329

Ref: TR-L379705

2'-Deoxy-3'-O-levulinoylthymidine

CAS: 78635-98-0

2'-Deoxy-3'-O-levulinoylthymidine is a novel antiviral agent and a synthetic deoxyribonucleoside that is structurally similar to thymidine. It has been studied in vitro and in vivo for its antiviral activity against various viruses, including HIV type 1, HIV type 2, herpes simplex virus (HSV), varicella zoster virus (VZV), cytomegalovirus (CMV), and influenza A virus. 2'-Deoxy-3'-O-levulinoylthymidine has also shown anticancer properties in vitro. This drug inhibits the synthesis of DNA by competing with other nucleotides for incorporation into DNA during the elongation phase of replication. It also inhibits the synthesis of RNA by competing with other nucleotides for incorporation into RNA during transcription.

Formula: C₁₅H₂₀N₂O₇

Purity: Min. 95%

Molecular weight: 340.33 g/mol

Ref: 3D-ND16367