CAS 78664-73-0

Posatirelin

Description:

Posatirelin, also known as TRH (thyrotropin-releasing hormone), is a synthetic peptide that plays a crucial role in the regulation of thyroid function and the release of thyroid-stimulating hormone (TSH) from the pituitary gland. It is composed of three amino acids: pyroglutamic acid, histidine, and proline. Posatirelin is typically administered via injection and is used in various clinical settings, including the assessment of pituitary function and the treatment of certain thyroid disorders. The substance is characterized by its ability to stimulate the release of TSH, which in turn promotes the production of thyroid hormones from the thyroid gland. Its pharmacological effects are primarily mediated through specific receptors in the hypothalamus and pituitary gland. Posatirelin is generally well-tolerated, but like any peptide, it may have side effects, including allergic reactions or injection site reactions. As a research tool, it has been valuable in studying the neuroendocrine regulation of thyroid hormones and their broader implications in metabolic processes.

Formula: C₁₇H₂₈N₄O₄

InChI: InChI=1/C17H28N4O4/c1-10(2)9-12(17(25)21-8-4-6-13(21)15(18)23)20-16(24)11-5-3-7-14(22)19-11/h10-13H,3-9H2,1-2H3,(H2,18,23)(H,19,22)(H,20,24)/t11-,12-,13-/m0/s1

InChI key: InChIKey=DPNGIIPSQYKWQA-AVGNSLFASA-N

SMILES: C([C@@H](NC(=O)[C@H]1NC(=O)CCC1)CC(C)C)(=O)N2[C@H](C(N)=O)CCC2

Synonyms:

• (-)-(2S)-N-(1S)-1-((2S)-2-Carbamoyl-1-pyrrolidinyl)carbonyl-3-(methylbutyl)-6-oxopipecolamide
• (2S)-6-Oxo-2-piperidinecarbonyl-<span class="text-smallcaps">L</smallcap>-leucyl-<smallcap>L</span>-prolinamide
• (S)-L-Leucyl-N-((6-oxo-2-piperidinyl)carbonyl)-L-prolinamide
• <span class="text-smallcaps">L</smallcap>-6-Ketopiperidine-2-carbonyl-<smallcap>L</smallcap>-leucyl-<smallcap>L</span>-proline amide
• <span class="text-smallcaps">L</smallcap>-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-<smallcap>L</span>-leucyl-
• <span class="text-smallcaps">L</smallcap>-Prolinamide, N-[(6-oxo-2-piperidinyl)carbonyl]-<smallcap>L</span>-leucyl-, (S)-
• Brn 6006446
• L-6-Ketopiperidine-2-carbonyl-leucyl-L-prolin-amide
• L-Prolinamide, N-((6-oxo-2-piperidinyl)carbonyl)-L-leucyl-, (S)-
• L-Pyro-2-aminoadipyl-L-leucyl-L-prolinamide
• N-{[(2S)-6-oxopiperidin-2-yl]carbonyl}-L-leucyl-L-prolinamide
• Posatirelin [INN]
• Posatirelina
• Posatirelina [INN-Spanish]
• Posatireline
• Posatireline [INN-French]
• Posatirelinum
• Posatirelinum [INN-Latin]
• Rgh-2202
• Unii-78U6302Arl
• Posatirelin
• (2S)-6-Oxo-2-piperidinecarbonyl-L-leucyl-L-prolinamide
• L-Prolinamide, (2S)-6-oxo-2-piperidinecarbonyl-L-leucyl-
• N-[6-Oxopiperidin-2(S)-Ylcarbonyl]-L-Leucyl-L- Prolinamide

Posatirelin

CAS: 78664-73-0

Posatirelin

Purity: ≥98%

Molecular weight: 352.43g/mol

Ref: 54-BUP02663

Posatirelin

Controlled Product

CAS: 78664-73-0

Formula: C₁₇H₂₈N₄O₄

Color and Shape: Neat

Molecular weight: 352.429

Ref: TR-P689665

Posatirelin

CAS: 78664-73-0

Posatirelin is a drug that is used to treat the symptoms of Parkinson's disease, including motor and non-motor symptoms. It has been shown to be effective in improving motor skills, reducing tremors and stiffness, improving speech and cognitive function, and increasing energy levels. This drug is administered as an injection into the muscle or under the skin. The most common side effects are pain at the site of injection, headache, dizziness, nausea, vomiting and sleepiness. Posatirelin is metabolized by cytochrome P450 enzymes in the liver and excreted in urine as metabolites. It should not be taken with other drugs that induce these enzymes such as carbamazepine or phenytoin because this will increase posatirelin blood levels and lead to toxicity. Posatirelin does not interact with any drugs currently on the market for Parkinson's disease treatment; however it may interact with some other drugs that are not on the market for this purpose. The

Formula: C₁₇H₂₈N₄O₄

Purity: Min. 95%

Molecular weight: 352.4 g/mol

Ref: 3D-DDA66473

Posatirelin

CAS: 78664-73-0

Posatirelin, a synthetic peptide, modulates and nourishes brain systems, aiding in vascular dementia research.

Formula: C₁₇H₂₈N₄O₄

Purity: 99.43% - 99.95%

Color and Shape: Solid

Molecular weight: 352.43

Ref: TM-T34114