CymitQuimica logo

CAS 78684-63-6

:

(-)-Mianserin

Description:
(-)-Mianserin is a tetracyclic antidepressant primarily used in the treatment of major depressive disorder. It is characterized by its unique chemical structure, which includes a dibenzocycloheptene core. The compound exhibits a chiral center, with the (-)-enantiomer being the biologically active form. (-)-Mianserin functions primarily as an antagonist at various neurotransmitter receptors, including serotonin (5-HT2) and norepinephrine receptors, which contributes to its antidepressant effects. Additionally, it has antihistaminic properties, which can lead to sedation, making it useful for patients with insomnia associated with depression. The substance is typically administered orally and has a moderate half-life, allowing for once-daily dosing in many cases. Common side effects may include sedation, weight gain, and dry mouth, among others. Due to its pharmacological profile, (-)-Mianserin is considered a second-line treatment option, particularly for patients who do not respond to first-line antidepressants. As with any medication, it is essential to use (-)-Mianserin under the guidance of a healthcare professional.
Formula:C18H20N2
InChI:InChI=1S/C18H20N2/c1-19-10-11-20-17-9-5-3-7-15(17)12-14-6-2-4-8-16(14)18(20)13-19/h2-9,18H,10-13H2,1H3/t18-/m0/s1
InChI key:InChIKey=UEQUQVLFIPOEMF-SFHVURJKSA-N
SMILES:CN1C[C@@]2(N(C=3C(CC=4C2=CC=CC4)=CC=CC3)CC1)[H]
Synonyms:
  • (-)-(R)-Mianserin
  • (-)-Mianserin
  • (14bR)-1,2,3,4,10,14b-Hexahydro-2-methyldibenzo[c,f]pyrazino[1,2-a]azepine
  • Dibenzo(c,f)pyrazino(1,2-a)azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (14bR)-
  • Dibenzo[c,f]pyrazino[1,2-a]azepine, 1,2,3,4,10,14b-hexahydro-2-methyl-, (R)-
Sort by
The purity filter is not visible because current products do not have associated purity data for filtering.
Found 2 products.
  • (R)-Mianserin
    TLC
    + Info

    (R)-Mianserin

    CAS:
    Formula:C18H20N2
    Color and Shape:White To Off-White Solid
    Molecular weight:264.37

    Ref: 4Z-M-099

    5mg
    To inquire
    10mg
    698.00€
    25mg
    1,153.00€
    50mg
    2,002.00€
    100mg
    To inquire
  • (R)-(+)-Mianserin
    TRC
    + Info

    (R)-(+)-Mianserin

    Controlled Product
    CAS:

    Applications (R)-(+)-Mianserin is serotonin receptor antagonist. Antidepressant.
    References Saxena, et al.: Eur. J. Pharmacol., 13, 295 (1971), Brogden, R.N., et al.: Drugs, 16, 273 (1978), Alexander, B.S., et al.: J. Pharm. Pharmacol., 39, 664 (1987)

    Formula:C18H20N2
    Color and Shape:Neat
    Molecular weight:264.365

    Ref: TR-M341515

    250mg
    3,477.00€