CAS 78755-81-4

Flumazenil

Description:

Flumazenil is a benzodiazepine derivative primarily known for its role as a competitive antagonist of the benzodiazepine receptor. It is commonly used in clinical settings to reverse the effects of benzodiazepine overdose or sedation. The substance is characterized by its ability to displace benzodiazepines from their binding sites on the GABA-A receptor, thereby counteracting their sedative effects. Flumazenil is typically administered intravenously and has a relatively short half-life, which necessitates careful monitoring and potential repeated dosing in cases of overdose. Its chemical structure includes a 1,3-benzodiazepine core, contributing to its pharmacological properties. While it is effective in reversing sedation, flumazenil can precipitate withdrawal symptoms in individuals dependent on benzodiazepines and may not be effective against all types of sedative overdoses. Additionally, it is contraindicated in patients with a history of seizures or those who have taken certain medications, such as tricyclic antidepressants. Overall, flumazenil is a critical tool in emergency medicine for managing benzodiazepine-related complications.

Formula: C₁₅H₁₄FN₃O₃

InChI: InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key: InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C1=C2N(C=3C(C(=O)N(C)C2)=CC(F)=CC3)C=N1

Synonyms:

• 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
• 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
• Anexate
• FMZ
• Flumazepil
• Flumenazil
• Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
• Lanexat
• Mazicon
• Ro 15-1788
• Ro 15-1788/000
• Ro 151788
• Ro 1722
• Ro 41-8157
• Romazicon
• acid ethyl ester
• ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
• Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
• acid ethyl ester

Flumazenil

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Purity: >99.0%(GC)

Color and Shape: White to Almost white powder to crystal

Molecular weight: 303.29

Ref: 3B-F0958

Flumazenil, 98%

CAS: 78755-81-4

Benzodiazepine antagonist

Formula: C₁₅H₁₄FN₃O₃

Purity: 98%

Color and Shape: Powder

Molecular weight: 303.29

Ref: 02-J62537

Flumazenil, 1mg/ml in Ethanol

CAS: 78755-81-4

Color and Shape: Single Solution

Ref: LP-FLM-115-1LE

Flumazenil

CAS: 78755-81-4

Aromatic or modified aromatic drugs with nitrogen hetero-atom(s) only, not elsewhere specified or included

Formula: C₁₅H₁₄FN₃O₃

Color and Shape: White Off-White Powder

Molecular weight: 303.10192

Ref: 45-1273808

Flumazenil

CAS: 78755-81-4

Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous

Formula: C₁₅H₁₄FN₃O₃

Purity: 99.72% - 99.98%

Color and Shape: Less Crystals Colourless Crystals

Molecular weight: 303.29

Ref: TM-T1240

Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Purity: 95%

Color and Shape: Solid

Molecular weight: 303.2884

Ref: IN-DA005JF1

Flumazenil-d5

CAS: 78755-81-4

Formula: C₁₅H₉D₅FN₃O₃

Color and Shape: White To Off-White Solid

Molecular weight: 308.32

Ref: 4Z-F-070007

Flumazenil

CAS: 78755-81-4

Flumazenil

Purity: 99%

Molecular weight: 303.29g/mol

Ref: 54-PC108878

Flumazenil

CAS: 78755-81-4

Flumazenil

Purity: ≥98%

Molecular weight: 303.29g/mol

Ref: 54-BUP14150

Flumazenil

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Color and Shape: White To Off-White Solid

Molecular weight: 303.30

Ref: 4Z-F-070003

Flumazenil

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Purity: ≥ 98.0%

Color and Shape: White to off-white powder

Molecular weight: 303.29

Ref: 7W-GP1380

Flumazenil

CAS: 78755-81-4

Color and Shape: Neat

Ref: 61-FOR0762.00

Flumazenil

CAS: 78755-81-4

Color and Shape: Neat

Ref: LP-FLM-115-10

Flumazenil

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Color and Shape: Neat

Molecular weight: 303.29

Ref: 04-C13717900

Flumazenil

CAS: 78755-81-4

Color and Shape: Neat

Ref: 86-MM0762.00

Flumazenil

Controlled Product

CAS: 78755-81-4

Applications Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.
References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),

Formula: C₁₅H₁₄FN₃O₃

Color and Shape: Off White

Molecular weight: 303.29

Ref: TR-F500450

Flumazenil

CAS: 78755-81-4

Purity: 99.0%

Color and Shape: Solid

Molecular weight: 303.2929992675781

Ref: 10-F047168

Flumazenil

CAS: 78755-81-4

Formula: C₁₅H₁₄FN₃O₃

Ref: TR-TRC-F500450

Flumazenil-D5

Controlled Product

CAS: 78755-81-4

Applications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.
References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)

Formula: C₁₅H₉D₅FN₃O₃

Color and Shape: Neat

Molecular weight: 303.29

Ref: TR-F500452

Flumazenil

Controlled Product

CAS: 78755-81-4

Benzodiazepine antagonist

Formula: C₁₅H₁₄FN₃O₃

Purity: Min. 98 Area-%

Color and Shape: White Powder

Molecular weight: 303.29 g/mol

Ref: 3D-FF23326

Flumazenil - Bio-X ™

Controlled Product

CAS: 78755-81-4

Flumazenil is a drug that reverses the effects of benzodiazepines, such as diazepam, lorazepam, and midazolam. It binds to the α1 subunit of the GABA receptor and prevents it from opening. Flumazenil is a benzodiazepine antagonist.

Formula: C₁₅H₁₄FN₃O₃

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 303.29 g/mol

Ref: 3D-BF164469

Flumazenil-D3

Controlled Product

CAS: 78755-81-4

Applications Flumazenil-D3 is an intermediate in the synthesis of Flumazenil Carboxylic Acid-D3 (F500457), which is an isotope labelled form of Flumazenil Carboxylic Acid (F500455); a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.
References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)

Formula: C₁₅D₃H₁₁FN₃O₃

Color and Shape: Neat

Molecular weight: 306.307

Ref: TR-F500451