CAS 78755-81-4
:Flumazenil
Description:
Flumazenil is a benzodiazepine derivative primarily known for its role as a competitive antagonist of the benzodiazepine receptor. It is commonly used in clinical settings to reverse the effects of benzodiazepine overdose or sedation. The substance is characterized by its ability to displace benzodiazepines from their binding sites on the GABA-A receptor, thereby counteracting their sedative effects. Flumazenil is typically administered intravenously and has a relatively short half-life, which necessitates careful monitoring and potential repeated dosing in cases of overdose. Its chemical structure includes a 1,3-benzodiazepine core, contributing to its pharmacological properties. While it is effective in reversing sedation, flumazenil can precipitate withdrawal symptoms in individuals dependent on benzodiazepines and may not be effective against all types of sedative overdoses. Additionally, it is contraindicated in patients with a history of seizures or those who have taken certain medications, such as tricyclic antidepressants. Overall, flumazenil is a critical tool in emergency medicine for managing benzodiazepine-related complications.
Formula:C15H14FN3O3
InChI:InChI=1S/C15H14FN3O3/c1-3-22-15(21)13-12-7-18(2)14(20)10-6-9(16)4-5-11(10)19(12)8-17-13/h4-6,8H,3,7H2,1-2H3
InChI key:InChIKey=OFBIFZUFASYYRE-UHFFFAOYSA-N
SMILES:C(OCC)(=O)C1=C2N(C=3C(C(=O)N(C)C2)=CC(F)=CC3)C=N1
Synonyms:- 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 8-fluoro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
- 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
- Anexate
- FMZ
- Flumazepil
- Flumenazil
- Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
- Lanexat
- Mazicon
- Ro 15-1788
- Ro 15-1788/000
- Ro 151788
- Ro 1722
- Ro 41-8157
- Romazicon
- acid ethyl ester
- ethyl 8-fluoro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
- 8-Fluoro-5,6-dihydro-5-methyl-6-oxo-4H-
- Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic
- acid ethyl ester
- See more synonyms
Sort by
Purity (%)
0
100
|
0
|
50
|
90
|
95
|
100
Found 21 products.
Flumazenil
CAS:Formula:C15H14FN3O3Purity:>99.0%(GC)Color and Shape:White to Almost white powder to crystalMolecular weight:303.29Flumazenil, 98%
CAS:<p>Benzodiazepine antagonist</p>Formula:C15H14FN3O3Purity:98%Color and Shape:PowderMolecular weight:303.29Flumazenil
CAS:<p>Aromatic or modified aromatic drugs with nitrogen hetero-atom(s) only, not elsewhere specified or included</p>Formula:C15H14FN3O3Color and Shape:White Off-White PowderMolecular weight:303.10192Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
CAS:Formula:C15H14FN3O3Purity:95%Color and Shape:SolidMolecular weight:303.2884Ref: IN-DA005JF1
1g300.00€5gTo inquire1mg38.00€25gTo inquire50gTo inquire5mg44.00€10mg54.00€100mg82.00€250mg139.00€Flumazenil
CAS:<p>Flumazenil (Ro 15-1788) antagonizes the benzodiazepine binding site of the gamma-aminobutyric acid (GABA)/benzodiazepine receptor complex in the central nervous</p>Formula:C15H14FN3O3Purity:99.72% - 99.98%Color and Shape:Less Crystals Colourless CrystalsMolecular weight:303.29Flumazenil-d5
CAS:Formula:C15H9D5FN3O3Color and Shape:White To Off-White SolidMolecular weight:308.32Flumazenil
CAS:Formula:C15H14FN3O3Purity:≥ 98.0%Color and Shape:White to off-white powderMolecular weight:303.29Flumazenil
CAS:Controlled Product<p>Applications Flumazenil is an imidazodiazepine which selectively blocks the central effects of classic benzodiazepines. It is used as benzodiazepine antagonist.<br>References Hunkeler, W., et al.: Nature, 290, 514 (1981), Pole, P., et al.: Arch. Pharmacol., 316, 317 (1981), Timm, U., et al.: Arzneim.-Forsch., 33, 358 (1983),<br></p>Formula:C15H14FN3O3Color and Shape:Off WhiteMolecular weight:303.29Flumazenil-D5
CAS:Controlled Product<p>Applications Flumazenil-D5 is a labelled analogue of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>Formula:C15H9D5FN3O3Color and Shape:NeatMolecular weight:303.29Flumazenil - Bio-X ™
CAS:Controlled Product<p>Flumazenil is a drug that reverses the effects of benzodiazepines, such as diazepam, lorazepam, and midazolam. It binds to the α1 subunit of the GABA receptor and prevents it from opening. Flumazenil is a benzodiazepine antagonist.</p>Formula:C15H14FN3O3Purity:Min. 95%Color and Shape:PowderMolecular weight:303.29 g/molFlumazenil
CAS:Controlled Product<p>Benzodiazepine antagonist</p>Formula:C15H14FN3O3Purity:Min. 98 Area-%Color and Shape:White PowderMolecular weight:303.29 g/molFlumazenil-D3
CAS:Controlled Product<p>Applications Flumazenil-D3 is an intermediate in the synthesis of Flumazenil Carboxylic Acid-D3 (F500457), which is an isotope labelled form of Flumazenil Carboxylic Acid (F500455); a derivative of Flumazenil (F500450), a benzodiazepine antagonist that can prevent or abolish (at the receptor level) the effects of a benzodiazepine.<br>References Brogden, R. & Goa, K.: Drugs, 35, 448 (1988); Klotz, U. & Kanto, J.: Clin. Pharmacokinet., 14, 1 (1988)<br></p>Formula:C15D3H11FN3O3Color and Shape:NeatMolecular weight:306.307
![Ethyl 8-fluoro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate](/_next/image/?url=https%3A%2Fstatic.cymitquimica.com%2Fproducts%2FIN%2Fthumb%2FDA005JF1.jpg&w=3840&q=75)
