CAS 78761-59-8

11α,17α,21-Trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione

Description:

11α,17α,21-Trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione, commonly known as methylprednisolone, is a synthetic glucocorticoid with anti-inflammatory and immunosuppressive properties. It is characterized by its steroidal structure, which includes a pregnane backbone with hydroxyl groups at the 11, 17, and 21 positions, and a methyl group at the 16α position. This compound is often used in clinical settings to treat various conditions, including allergies, autoimmune disorders, and inflammatory diseases. Methylprednisolone functions by modulating gene expression and inhibiting the release of inflammatory mediators, thereby reducing inflammation and immune responses. It is typically administered orally or via injection, and its pharmacokinetics can vary based on the route of administration. The compound is known for its potency and relatively favorable side effect profile compared to other corticosteroids, making it a valuable therapeutic agent in medicine. However, long-term use can lead to potential side effects, including adrenal suppression and metabolic changes.

Formula: C₂₂H₃₀O₅

InChI: InChI=1S/C22H30O5/c1-12-8-16-15-5-4-13-9-14(24)6-7-20(13,2)19(15)17(25)10-21(16,3)22(12,27)18(26)11-23/h6-7,9,12,15-17,19,23,25,27H,4-5,8,10-11H2,1-3H3/t12-,15+,16+,17-,19-,20+,21+,22+/m1/s1

InChI key: InChIKey=WNYLPFCKNQAAMB-JPDWDDBRSA-N

SMILES: C[C@@]12[C@]([C@]3([C@]([C@H](O)C1)([C@]4(C)C(CC3)=CC(=O)C=C4)[H])[H])(C[C@@H](C)[C@@]2(C(CO)=O)O)[H]

Synonyms:

• (11Α,16Α)-11,17,21-Trihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
• 11α,17α,21-Trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione
• 278-982-7
• Pregna-1,4-diene-3,20-dione, 11,17,21-trihydroxy-16-methyl-, (11α,16α)-

Desoximetasone Impurity 13

CAS: 78761-59-8

Formula: C₂₂H₃₀O₅

Molecular weight: 374.48

Ref: 4Z-D-113024

11Alpha,17Alpha,21-Trihydroxy-16Alpha-methyl-1,4-pregnadiene-3,20-dione

Controlled Product

CAS: 78761-59-8

Applications 11α,17α,21-Trihydroxy-16α-methyl-1,4-pregnadiene-3,20-dione is a 3-Keto-Δ1(2)-Δ4(5) steroid that can be synthesized from Dexamethasone 9,11-Epoxide (D298795).

Formula: C₂₂H₃₀O₅

Color and Shape: Neat

Molecular weight: 374.47

Ref: TR-T795365

(11alpha,16alpha)-11,17,21-Trihydroxy-16-methylpregna-1,4-diene-3,20-dione

Controlled Product

CAS: 78761-59-8

Triamcinolone is a corticosteroid that is used to treat inflammatory conditions such as asthma, rheumatoid arthritis and ulcerative colitis. It is also used for the treatment of certain skin disorders. Triamcinolone binds to the glucocorticoid receptor, which then enters the cell nucleus and binds to specific DNA sequences, inhibiting transcription and protein synthesis. Triamcinolone can also inhibit replication of viruses that are members of the Hantavirus family by binding to their nucleotide sequence in the host cell nucleus. This drug has been found to be effective against animal hantaviruses such as Apodemus agrarius but not human hantaviruses such as Sin Nombre virus.

Formula: C₂₂H₃₀O₅

Purity: Min. 95%

Molecular weight: 374.47 g/mol

Ref: 3D-FD177117

Dexamethasone Desfluoro 11-Epimer

CAS: 78761-59-8

Formula: C₂₂H₃₀O₅

Molecular weight: 374.48

Ref: ST-EA-CP-D17058