CAS 78771-13-8

Sarmazenil

Description:

Sarmazenil, with the CAS number 78771-13-8, is a chemical compound that functions primarily as a selective antagonist of the benzodiazepine receptor. It is known for its role in pharmacology, particularly in the context of reversing the effects of benzodiazepines, which are commonly used for their anxiolytic, sedative, and muscle relaxant properties. Sarmazenil exhibits a high affinity for the benzodiazepine site on the GABA-A receptor, allowing it to effectively counteract the sedative effects of benzodiazepines without producing significant anxiolytic or sedative effects itself. This makes it a valuable tool in clinical settings, particularly in cases of benzodiazepine overdose or when rapid reversal of sedation is required. The compound is typically administered via intravenous routes and has been studied for its potential applications in various therapeutic contexts. As with any pharmacological agent, its use must be carefully monitored to manage potential side effects and interactions with other medications.

Formula: C₁₅H₁₄ClN₃O₃

InChI: InChI=1/C15H14ClN3O3/c1-3-22-15(21)13-11-7-18(2)14(20)12-9(16)5-4-6-10(12)19(11)8-17-13/h4-6,8H,3,7H2,1-2H3

InChI key: InChIKey=WSDBAFQWNWJTNG-UHFFFAOYSA-N

SMILES: C(OCC)(=O)C1=C2N(C=3C(C(=O)N(C)C2)=C(Cl)C=CC3)C=N1

Synonyms:

• 4H-Imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid, 7-chloro-5,6-dihydro-5-methyl-6-oxo-, ethyl ester
• Ethyl 7-chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo-(1,5-a)(1,4)benzodiazepine-3-carboxylate
• Ro 15-3505
• Sarmazenil [INN]
• Sarmazenilum
• Sarmazenilum [INN-Latin]
• Unii-F84Ae7X24P
• ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate
• Sarmazenil
• ethyl 7-chloro-5-methyl-6-oxo-5,6-dihydro-4H-benzo[f]imidazo[1,5-a][1,4]diazepine-3-carboxylate(WXG00129)
• 7-Chloro-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylic acid ethyl ester

Sarmazenil

CAS: 78771-13-8

Sarmazenil

Purity: ≥98%

Molecular weight: 319.74g/mol

Ref: 54-BUP05052

Sarmazenil

CAS: 78771-13-8

Sarmazenil is a benzodiazepine antagonist that competes with the binding of benzodiazepines to the gamma-aminobutyric acid (GABA) receptor. It has been shown to have antidepressant effects in animals, and may be useful for treating depression by preventing the enhancement of GABA-mediated neurotransmission. Sarmazenil is also used to reverse the sedative effects of benzodiazepines, such as diazepam, and can be administered intravenously or intramuscularly. This drug binds to receptors at the occipital cortex, leading to an increase in cortisol concentration. Sarmazenil has a high affinity for GABA receptors and acts as a competitive inhibitor of other ligands that bind these receptors. It is structurally similar to diazepam and has been shown to reverse its depressant effect on locomotor activity in rats.

Formula: C₁₅H₁₄ClN₃O₃

Purity: Min. 95%

Molecular weight: 319.74 g/mol

Ref: 3D-DDA77113

Sarmazenil

CAS: 78771-13-8

Sarmazenil (Ro 15-3505) is a partial inverse agonist at the benzodiazepine receptor and is used in the study of chronic hepatic encephalopathy.

Formula: C₁₅H₁₄ClN₃O₃

Purity: 99.46%

Color and Shape: Solid

Molecular weight: 319.74

Ref: TM-T16844