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CAS 78897-52-6

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Leucomycin A13

Description:
Leucomycin A13 is a macrolide antibiotic that is derived from the fermentation of the bacterium *Streptomyces aureofaciens*. It exhibits antibacterial properties, primarily effective against Gram-positive bacteria and some Gram-negative strains. The structure of Leucomycin A13 features a large lactone ring, which is characteristic of macrolides, and it contains multiple hydroxyl and methoxy groups that contribute to its biological activity. This compound is known for its ability to inhibit bacterial protein synthesis by binding to the 50S ribosomal subunit, thereby interfering with the translation process. Leucomycin A13 is often used in clinical settings to treat various infections, particularly those caused by resistant strains of bacteria. Its pharmacokinetics include good oral bioavailability and a relatively long half-life, allowing for effective dosing regimens. However, like other antibiotics, it may lead to side effects and the development of resistance if not used judiciously. Overall, Leucomycin A13 represents an important tool in the antibiotic arsenal against bacterial infections.
Formula:C41H69NO14
InChI:InChI=1/C41H69NO14/c1-10-11-13-18-31(46)54-39-27(5)52-33(23-41(39,6)49)55-36-26(4)53-40(35(48)34(36)42(7)8)56-37-28(19-20-43)21-24(2)29(44)17-15-12-14-16-25(3)51-32(47)22-30(45)38(37)50-9/h12,14-15,17,20,24-30,33-40,44-45,48-49H,10-11,13,16,18-19,21-23H2,1-9H3/b14-12+,17-15+/t24-,25-,26-,27+,28+,29+,30-,33+,34-,35-,36-,37+,38+,39+,40+,41-/m1/s1
InChI key:InChIKey=CUDHGRIZNLIHBG-TYBIZVFLSA-N
SMILES:O([C@H]1[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@@H](O)[C@@H]1OC)[C@H]2[C@H](O)[C@@H](N(C)C)[C@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(CCCCC)=O)[C@H](C)O3)[C@@H](C)O2
Synonyms:
  • Oxacyclohexadecane, leucomycin V deriv.
  • Leucomycin A13
  • Leucomycin V, 4B-hexanoate
  • See more synonyms
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