CAS 78919-13-8

Iloprost

Description:

Iloprost is a synthetic analog of prostacyclin (PGI2), primarily used for its vasodilatory and anti-platelet aggregation properties. It is characterized by its ability to mimic the effects of natural prostacyclin, leading to the relaxation of vascular smooth muscle and inhibition of platelet activation. Iloprost is typically administered via inhalation or intravenous routes and is utilized in the treatment of pulmonary arterial hypertension and other conditions requiring vasodilation. The substance has a relatively short half-life, necessitating continuous infusion or multiple doses for sustained therapeutic effects. Its chemical structure includes a bicyclic ring system, which contributes to its biological activity. Iloprost is known for its side effects, which may include headache, flushing, and gastrointestinal disturbances. Due to its potent effects on the cardiovascular system, careful monitoring is essential during treatment. Overall, Iloprost represents a significant therapeutic option in managing conditions associated with impaired blood flow and vascular dysfunction.

Formula: C₂₂H₃₂O₄

InChI: InChI=1S/C22H32O4/c1-3-4-7-15(2)20(23)11-10-18-19-13-16(8-5-6-9-22(25)26)12-17(19)14-21(18)24/h8,10-11,15,17-21,23-24H,5-7,9,12-14H2,1-2H3,(H,25,26)/b11-10+,16-8+/t15?,17-,18+,19-,20+,21+/m0/s1

InChI key: InChIKey=HIFJCPQKFCZDDL-ACWOEMLNSA-N

SMILES: C(=C/[C@H](C(CC#CC)C)O)\[C@@H]1[C@@]2([C@@](C/C(=C\CCCC(O)=O)/C2)(C[C@H]1O)[H])[H]

Synonyms:

• (1S,2R,3R,5S)-7-[(E)-4-Carboxybutylidene]-2-[(3S,1E)-3-hydroxy-4-methyl-6-octyn-1-enyl]-bicyclo[3.3.0]octane
• (5E)-5-[(3aS,4R,5R,6aS)-Hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]pentanoic acid
• (5E)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• (5Z)-5-[(3aS,5R,6aS)-5-hydroxy-4-[(1E,3R)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl]hexahydropentalen-2(1H)-ylidene]pentanoic acid
• Ciloprost
• Endoprost
• Ilomedin
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-yn-1-yl]-2(1H)-pentalenylidene]-, (5E)-
• Pentanoic acid, 5-[(3aS,4R,5R,6aS)-hexahydro-5-hydroxy-4-[(1E,3S)-3-hydroxy-4-methyl-1-octen-6-ynyl]-2(1H)-pentalenylidene]-, (5E)-
• Zk 36374

Iloprost

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Purity: 98%

Color and Shape: Liquid

Molecular weight: 360.4871

Ref: IN-DA0054KQ

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

CAS: 78919-13-8

(E)-5-((3aS,4R,5R,6aS)-5-Hydroxy-4-((3S,E)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl)hexahydropentalen-2(1H)-ylidene)pentanoic acid

Purity: 98%

Molecular weight: 360.49g/mol

Ref: 54-OR1062959

Iloprost

CAS: 78919-13-8

Formula: C₂₂H₃₂O₄

Molecular weight: 360.49

Ref: 4Z-I-098001

Iloprost

CAS: 78919-13-8

Stability Light and Temperature Sensitive
Applications A synthetic analogue of Prostacyclin (PGI2) used to treat pulmonary arterial hypertension (PAH), scleroderma, Raynaud's phenomenon and ischemia. It acts through elevation of cAMP by binding to the prostacyclin receptor (IP receptor). Iloprost inhibits the ADP, thrombin, and collagen-induced aggregation of human platelets with an ED50 of about 13 nM. In whole animals, iloprost acts as a vasodilator, hypotensive, antidiuretic, and prolongs bleeding time.
References Zamudio, T.P.: Arch. Cardiol. Mex., 77, 198 (2007); Lai, Y. et al.: Am. J. Resp. Crit. Care Med., 178, 188 (2008); Scorza, R. et al.: J. Rheutamol., 24, 1944 (1997); Melillo, E. et al.: Int. J. Microcircul. Clin. Exp., 15, 60 (1995);

Formula: C₂₂H₃₂O₄

Color and Shape: Colourless To Light Yellow

Molecular weight: 360.49

Ref: TR-I267300

Iloprost

CAS: 78919-13-8

Iloprost is a cyclase inhibitor that is used to treat pulmonary hypertension. It relaxes the smooth muscle cells in the lungs, which causes an increase in blood flow and oxygen levels to the heart and other organs. Iloprost also decreases the production of PGE2 and lowers blood pressure. Iloprost has been shown to be effective in treating chronic viral hepatitis and pulmonary diseases such as primary pulmonary hypertension. This drug can cause hypotension, so it should not be taken by patients with low blood pressure or those who are taking other drugs that can cause hypotension.

Formula: C₂₂H₃₂O₄

Purity: Min. 95%

Color and Shape: Solidified Mass

Molecular weight: 360.49 g/mol

Ref: 3D-FH24541

Iloprost

CAS: 78919-13-8

Iloprost (Ciloprost) is an inhibitor of platelet aggregation and vasodilatation used in the study of cardiovascular disease.

Formula: C₂₂H₃₂O₄

Color and Shape: Colorless Oil

Molecular weight: 360.49

Ref: TM-T15560