CAS 78964-85-9

Fosfomycin tromethamine

Description:

Fosfomycin tromethamine is an antibiotic used primarily for the treatment of urinary tract infections. It is a derivative of fosfomycin, which is a broad-spectrum antibiotic that inhibits bacterial cell wall synthesis. The chemical structure of fosfomycin tromethamine includes a phosphonic acid group, which is crucial for its antibacterial activity. It is typically administered as a salt form to enhance its solubility and stability. The substance is known for its rapid absorption and excretion, allowing for effective treatment of infections. Fosfomycin tromethamine is effective against a variety of Gram-positive and Gram-negative bacteria, including strains resistant to other antibiotics. Its mechanism of action involves the inhibition of the enzyme MurA, which is essential for peptidoglycan synthesis in bacterial cell walls. This antibiotic is generally well-tolerated, with a low incidence of side effects, making it a valuable option in the treatment of uncomplicated urinary tract infections. However, like all antibiotics, its use should be guided by susceptibility patterns to avoid resistance development.

Formula: C₄H₁₁NO₃·C₃H₇O₄P

InChI: InChI=1S/C4H11NO3.C3H7O4P/c5-4(1-6,2-7)3-8;1-2-3(7-2)8(4,5)6/h6-8H,1-3,5H2;2-3H,1H3,(H2,4,5,6)/t;2-,3+/m.0/s1

InChI key: InChIKey=QZJIMDIBFFHQDW-LMLSDSMGSA-N

SMILES: P(=O)(O)(O)[C@@H]1[C@H](C)O1.C(CO)(CO)(CO)N

Synonyms:

• 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, (2R-cis)-(3-methyloxiranyl)phosphonate (1:1) (salt)
• 1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, [(2R,3S)-3-methyloxiranyl]phosphonate (1:1) (salt)
• 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium hydrogen [(2R,3S)-3-methyloxiran-2-yl]phosphonate
• Fosfomycin Trometamol
• Fosfomycin Tromethamine
• Fosfomycin compd. with trometamol
• Fosfomycin trometamol salt
• Fosfotricin
• Monuril
• Monurol
• Monurol Sachet
• Phosphonic acid, (3-methyloxiranyl)-, (2R-cis)-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
• Phosphonic acid, P-[(2R,3S)-3-methyl-2-oxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
• Phosphonic acid, [(2R,3S)-3-methyloxiranyl]-, compd. with 2-amino-2-(hydroxymethyl)-1,3-propanediol (1:1)
• Phosphonomycin monotrometamol
• Tromethamine-fosfomycin
• Z 1282

FOSFOMYCIN TROMETAMOL CRS

CAS: 78964-85-9

FOSFOMYCIN TROMETAMOL CRS

Formula: C₇H₁₈NO₇P

Color and Shape: White. Powder.

Molecular weight: 259.1941

Ref: 41-F0400000

Fosfomycin Tromethamine

CAS: 78964-85-9

Antibiotics nesoi

Formula: C₃H₇O₄P·C₄H₁₁NO₃

Color and Shape: White Off-White Powder

Molecular weight: 259.08209

Ref: 45-1286322

Fosfomycin Tromethamine

CAS: 78964-85-9

Fosfomycin Tromethamine

Purity: 98%

Molecular weight: 259.2g/mol

Ref: 54-OR1029654

Fosfomycin Tromethamine

CAS: 78964-85-9

Fosfomycin Tromethamine

Purity: ≥98%

Molecular weight: 259.19g/mol

Ref: 54-BUP13929

Fosfomycin tromethamine

CAS: 78964-85-9

Formula: C₇H₁₈NO₇P

Purity: (HPLC) 98.0 - 102.0 % (anhydrous substance)

Color and Shape: White or almost white powder

Molecular weight: 259.19

Ref: 7W-GP9120

Fosfomycin tromethamine

CAS: 78964-85-9

Formula: C₃H₇O₄P·C₄H₁₁NO₃

Molecular weight: 138.06 121.14

Ref: 4Z-F-4712

Fosfomycin Tromethamine

CAS: 78964-85-9

An antibiotic produced by Streptomyces fradiae.

Formula: C₇H₁₈NO₇P

Purity: 99.71% - 99.92%

Color and Shape: White Or Off-White Powder

Molecular weight: 259.19

Ref: TM-T4989

rac-Fosfomycin Tromethamine-d5

CAS: 78964-85-9

Formula: C₃H₂D₅O₄P·C₄H₁₁NO₃

Color and Shape: White To Off-White Solid

Molecular weight: 143.09 121.14

Ref: 4Z-F-4717

Fosfomycin Tromethamine

CAS: 78964-85-9

Stability Hygroscopic
Applications Fosfomycin Tromethamine is used as an antibiotic compound in the treatment of urinary tract infections.
References Keating, G. et al.: Drugs, 73, 1951 (2013); Demir, T. et al.: Int. J. Infect. Dis., 17, e966 (2013);

Formula: C₄H₁₁NO₃·C₃H₇O₄P

Color and Shape: Neat

Molecular weight: 259.19

Ref: TR-F727505

Fosfomycin Tromethamine

CAS: 78964-85-9

Formula: C₃H₇O₄PC₄H₁₁NO₃

Molecular weight: 138.06 : 121.14

Ref: ST-EA-CP-F6005

Fosfomycin trometamol

CAS: 78964-85-9

Fosfomycin is an antibiotic that is used to treat urinary tract infections caused by bacteria. It is a bactericidal antibiotic that works by inhibiting bacterial cell wall synthesis and, therefore, bacterial growth. Fosfomycin has been shown to be effective against both susceptible and resistant strains of bacteria. Resistance to fosfomycin develops quickly among bacteria, so it should not be used as the sole agent in the treatment of an infection. Fosfomycin should not be taken with sodium citrate because this will decrease its effectiveness. Symptoms of fosfomycin use may include nausea, vomiting, diarrhea or constipation.

Formula: C₇H₁₈NO₇P

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 259.19 g/mol

Ref: 3D-FF32180