CAS 78996-15-3

Tretinoin-d5 (Retinoic Acid-d5, Isotretinoin EP Impurity A-d5)

CAS: 302-79-4, 78996-15-3

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Pale Yellow Solid

Molecular weight: 305.47

Ref: 4Z-T-114002

Retinoic acid-d5

CAS: 78996-15-3

Retinoic acid-d5: deuterium-labeled, natural RAR agonist (IC50: 14 nM), affects cell growth and development, inhibits Nrf2.

Formula: C₂₀H₂₈O₂

Purity: 98%

Color and Shape: Soild

Molecular weight: 305.47

Ref: TM-T67921

all-trans-Retinoic Acid-d5 (major)

Controlled Product

CAS: 78996-15-3

Stability Light Sensitive, Temperature Sensitive
Applications An isotopically Labelled analog of retinoic acid. Physiological metabolite of vitamin A. Effects gene expression via nuclear retinoic acid receptors (RAR); mediates cellular growth and differentiation.A representative lot contains 11% d4, no d0 or d1 present.
References Kamm, J.J., et al.: J. Am. Acad. Dermatol., 6, 652 (1982), Warrel, R.P., et al.: Leukemia, 8, 929 (1994), Sasai, Y., et al.: J. Neurol., 249, 41 (2002),

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Neat

Molecular weight: 305.47

Ref: TR-R250202

11-cis-Retinoic Acid-d5

Controlled Product

CAS: 78996-15-3

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Neat

Molecular weight: 305.47

Ref: TR-R245022

9-cis,13-cis-Retinoic Acid-d5

Controlled Product

CAS: 78996-15-3

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Neat

Molecular weight: 305.47

Ref: TR-R245017

9-cis-Retinoic Acid-d5

Controlled Product

CAS: 78996-15-3

Applications An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.
References Heyman, R.A., et al.: Cell, 68, 397 (1992), Levin, A.A., et al.: Nature, 355, 359 (1992), Allenby, G., et al.: Proc. Natl. Acad. Sci. U.S.A., 90, 30 (1993)

Formula: C₂₀H₂₃D₅O₂

Color and Shape: Neat

Molecular weight: 305.47

Ref: TR-R245002

13-cis-Retinoic Acid-d5

Controlled Product

CAS: 78996-15-3

Stability Light Sensitive, Temperature Sensitive
Applications Used as a treatment for severe acne. Presently being studied in conjuction with the treatment of photoaged skin.
References Lerche, C., et al.: Exp. Dermatol., 17, 972 (2008), Sato, T., et al.: J. Med. Chem., 51, 7705 (2008), Gan, J., et al.: Chem. Res. Toxicol., 22, 690 (2009), Macejova, D., et al.: Toxicol. Lett., 184, 114 (2009), Chen, P., et al.: Toxicol. App. Pharmacol., 234, 143 (2009),

Formula: C₂₀D₅H₂₃O₂

Color and Shape: Neat

Molecular weight: 305.466

Ref: TR-R250002

all-trans-Retinoic Acid-d5 (major)

CAS: 78996-15-3

Formula: C₂₀H₂₃D₅O₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 305.4659

Ref: IN-DA01CCEI