CAS 790299-79-5

Masitinib

Description:

Masitinib is a small molecule tyrosine kinase inhibitor primarily known for its role in targeting specific receptor tyrosine kinases, including those involved in the signaling pathways of certain cancers and inflammatory diseases. It is characterized by its ability to selectively inhibit the activity of kinases such as c-KIT, which is implicated in various malignancies, and has shown promise in the treatment of conditions like mast cell tumors in dogs and certain forms of human cancer. Masitinib is typically administered orally and has a favorable pharmacokinetic profile, allowing for effective systemic absorption. Its mechanism of action involves blocking the phosphorylation of tyrosine residues, thereby disrupting downstream signaling pathways that promote cell proliferation and survival. The compound has undergone various clinical trials to assess its efficacy and safety, demonstrating potential benefits in both oncology and immunology. As with many targeted therapies, the side effects may vary, but they often include gastrointestinal disturbances and hematological changes. Overall, masitinib represents a significant advancement in the field of targeted cancer therapies and continues to be a subject of ongoing research.

Formula: C₂₈H₃₀N₆OS

InChI: InChI=1S/C28H30N6OS/c1-20-5-10-24(16-25(20)31-28-32-26(19-36-28)23-4-3-11-29-17-23)30-27(35)22-8-6-21(7-9-22)18-34-14-12-33(2)13-15-34/h3-11,16-17,19H,12-15,18H2,1-2H3,(H,30,35)(H,31,32)

InChI key: InChIKey=WJEOLQLKVOPQFV-UHFFFAOYSA-N

SMILES: N(C1=NC(=CS1)C=2C=CC=NC2)C3=CC(NC(=O)C4=CC=C(CN5CCN(C)CC5)C=C4)=CC=C3C

Synonyms:

• 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
• 4-[(4-methylpiperazin-1-yl)methyl]-N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)benzamide
• Benzamide, 4-[(4-methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]-
• MASITINIB 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide
• Masican
• Masiviera
• Masitinib

N-(4-methyl-3-{[4-(pyridin-3-yl)-1,3-thiazol-2-yl]amino}phenyl)-4-[(4-methylpiperazin-1-yl)methyl]benzamide

CAS: 790299-79-5

Formula: C₂₈H₃₀N₆OS

Purity: 95%

Color and Shape: Solid

Molecular weight: 498.6424

Ref: IN-DA0038FI

Masitinib

CAS: 790299-79-5

Masitinib

Purity: ≥95%

Molecular weight: 498.64g/mol

Ref: 54-BUP14486

Masitinib

CAS: 790299-79-5

Formula: C₂₈H₃₀N₆OS

Purity: >95.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 498.65

Ref: 3B-M3487

Masitinib

CAS: 790299-79-5

Masitinib (AB1010) is a tyrosine-kinase inhibitor used in the treatment of mast cell tumors in animals, specifically dogs.

Formula: C₂₈H₃₀N₆OS

Purity: 97.56% - >99.99%

Color and Shape: Solid

Molecular weight: 498.64

Ref: TM-T2609

Masitinib

CAS: 790299-79-5

Formula: C₂₈H₃₀N₆OS

Molecular weight: 498.65

Ref: 4Z-M-327001

Masatinib

CAS: 790299-79-5

Ref: 7W-GW8580

Masitinib

CAS: 790299-79-5

Masitinib is an orally bioavailable inhibitor of c-Kit, PDGFR and FGFR3 tyrosine. It is an antineoplastic which has been studied for applications in a range of human diseases including Alzheimers and cancer and is currently used to treat mast cell tumours in animals. As part of a screening study, Masitinib was shown to be highly effective in blocking SARs-CoV-2 replication.

Formula: C₂₈H₃₀N₆OS

Purity: Min. 98 Area-%

Color and Shape: Off-White To Gray Solid

Molecular weight: 498.64 g/mol

Ref: 3D-FM65073

Masitinib

CAS: 790299-79-5

Formula: C₂₈H₃₀N₆OS

Color and Shape: Neat

Molecular weight: 498.64

Ref: TR-M197500