CAS 79037-37-9

Estradiol-d3

Description:

Estradiol-d3, with the CAS number 79037-37-9, is a deuterated form of estradiol, a potent estrogen steroid hormone. It is characterized by the incorporation of three deuterium atoms, which are isotopes of hydrogen, replacing specific hydrogen atoms in the estradiol molecule. This modification enhances its stability and allows for more precise tracking in metabolic studies and research applications. Estradiol-d3 retains the biological activity of estradiol, playing a crucial role in the regulation of various physiological processes, including reproductive functions and bone health. It is often used in scientific research, particularly in studies involving hormone metabolism, pharmacokinetics, and the development of therapeutic agents. The presence of deuterium also aids in distinguishing it from non-deuterated forms in analytical techniques such as mass spectrometry. Overall, estradiol-d3 serves as a valuable tool in both clinical and laboratory settings for understanding estrogen-related pathways and effects.

Formula: C₁₈H₂₁D₃O₂

InChI: InChI=1/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14?,15-,16?,17+,18+/m1/s1/i7D2,17D

InChI key: InChIKey=VOXZDWNPVJITMN-SPGJGCHISA-N

SMILES: C[C@@]12[C@]([C@]3([C@@](C=4C(CC3)=CC(O)=CC4)(CC1)[H])[H])(CC([C@@]2(O)[2H])([2H])[2H])[H]

Synonyms:

• 17β-Estradiol-16,16,17-d3
• Estradiol-d3
• Estra-1,3,5(10)-triene-16,16,17-d3-3,17-diol, (17β)-
• (17β)-Estra-1,3,5(10)-triene-16,16,17-d3-3,17-diol
• Estraderm-d3
• B-ESTRADIOL-16,16,17-D3
• 1,3,5-Estratriene-3,17α-diol-d3
• BETA-ESTRADIOL-16,16,17-D3, 98 ATOM % D
• Cimara-d3
• (17b)-Estra-1,3,5(10)-triene-3,17-diol-d3
• Dihydrofolliculin-16,16,17-d3
• Estrofem-d3
• Alfatradiol-d3
• Estring-d3
• Evorel-d3
• Epiestrol-d3
• 1,3,5-Estratriene-3,17β-diol-16,16,17-d3
• 3,17α-Dihydroxyoestra-1,3,5(10)
• BETA-ESTRADIOL-16,16,17-D3
• 17-Estradiol--d3
• (17)-Estra-1,3,5(10)-triene-3,17-diol-d3
• 17-Epiestradiol-d3
• ESTRADIOL-D3, 25MG, NEAT
• Estrogel-d3
• NSC 20293-d3
• Estrace-d3
• 3,17-Epidihydroxyestratriene-d3
• Deuterated 17β-estradiol
• 17BETA-ESTRADIOL-16,16,17-D3
• Estra-1,3,5(10)-triene-3,17α-diol-d3
• -triene-d3
• Estradiol-[16,16,17-D3]
• 3,17β-Dihydroxy-1,3,5(10)-estratriene-16,16,17-d3
• Estradot-d3
• 3,17-Dihydroxyestratriene-d3
• Estradiol-[16,16,17-2H3]
• 13β-Methyl-1,3,5(10)-gonatriene-3,17α-diol-d3

Estradiol-d3 (Estradiol Valerate EP Impurity A-d3, Estriol EP Impurity D-d3, Ethinylestradiol EP Impurity D-d3)

CAS: 79037-37-9

Formula: C₁₈H₂₁D₃O₂

Color and Shape: White To Off-White Solid

Molecular weight: 275.41

Ref: 4Z-E-091

17β-Estradiol-16,16,17-d3(non marquée 50-28-2)

CAS: 79037-37-9

Purity: 98 atom % D

Color and Shape: White Solid

Molecular weight: 275.40

Ref: 3U-D2325

17-β-Estradiol D3 (16,16,17-D3)

Controlled Product

CAS: 79037-37-9

Formula: C₁₈H₃H₂₁O₂

Color and Shape: Neat

Molecular weight: 275.40

Ref: 04-C13213105

17-β-Estradiol D3 (16,16,17-D3) 100 µg/mL in Acetonitrile

Controlled Product

CAS: 79037-37-9

Formula: C₁₈H₃H₂₁O₂

Color and Shape: Single Solution

Molecular weight: 275.40

Ref: 04-A13213105AL-100

17β-Estradiol-16,16,17-d3

Controlled Product

CAS: 79037-37-9

Applications Isotope labelled 17β-Estradiol (E888000), which is the major estrogen (1) secreted by the premenopausal ovary (2).Drinking water contaminant candidate list 3 (CCL 3) compound as per United States Environmental Protection Agency (EPA), environmental, and food contaminants.
References 1. Salole, E. et al.: Anal. Profiles Drug Subs. 1986 15, 23 283-3182. Lievertz, R. et al.: Am. J. Obstet. Gynecol. 1987 May;156(5):1289-93.

Formula: C₁₈₂H₃H₂₁O₂

Color and Shape: Neat

Molecular weight: 275.4

Ref: TR-E888002

17alpha-Estradiol-16,16,17-d3

Controlled Product

CAS: 79037-37-9

Applications Labelled Estradiol. Estradiol (known as α-Estradiol or 17 α-Estradiol) is a biologically active estrogen in human breast cancer cells in tissue culture. 17-Εstradiol and its selective receptor, ER-X, are not part of a classical hormone/receptor endocrine system but of a system with important autocrine/paracrine functions in the developing and adult brain. 17-Estradiol may have enormous implications for hormone replacement strategies at the menopause and in the treatment of such neurodegenerative disorders as Alzheimer’s disease and ischemic stroke.
References Salole, E.G., Anal. Profiles Drug Subs., 15, 283 (1986), Lievertz, R.W., et al.: Am. J. Obstret. Gynecol., 156, 1289 (1987), Kuhnz, W., et al.: Arzneim.-Forsch., 43, 966 (1993),

Formula: C₁₈H₂₁D₃O₂

Color and Shape: Neat

Molecular weight: 275.4

Ref: TR-E887997

17²-Estradiol-16,16,17-d3

Controlled Product

CAS: 79037-37-9

17²-Estradiol-16,16,17-d3 is a derivative of estradiol. It is an organic solvent that can be synthesized in the lab or extracted from wastewater. This substance has estrogenic properties and can act as an agonist to many different estrogen receptors. The median concentrations of this substance in wastewater are high, as are the concentrations in pharmaceuticals such as triclosan and salicylic acid. 17²-Estradiol-16,16,17-d3 has been shown to have agonistic activities on PPARs and ERβ receptors. Optimization studies have been conducted using this compound for use in drug design.

Formula: C₁₈D₃H₂₁O₂

Purity: Min. 95%

Molecular weight: 275.4 g/mol

Ref: 3D-EDA03737