CAS 79079-11-1

Ac-calpastatin (184-210)

CAS: 79079-11-1

Ac-calpastatin (184-210) is a medicinal analog that has been shown to have anticancer properties. It acts as an inhibitor of calpain, which is a group of calcium-dependent cysteine proteases that play a role in various cellular processes such as apoptosis, cell migration, and signal transduction. Ac-calpastatin (184-210) has been found to inhibit the activity of various kinases that are involved in tumor growth and progression. This protein has been isolated from human urine and Chinese hamster ovary cells. Studies have shown that Ac-calpastatin (184-210) can induce apoptosis in cancer cells by suppressing the activity of calpain, leading to decreased cell viability and increased sensitivity to chemotherapy. This inhibitor holds great promise in the development of novel anticancer therapies.

Formula: C₇₅H₁₆₀N₂₃O₅

Purity: Min. 95%

Molecular weight: 1,464.2 g/mol

Ref: 3D-EDA07911

Ac-Calpastatin (184-210)

CAS: 79079-11-1

Calpastatin (184-210), an acetylated synthetic peptide derived from human calpastatin, effectively inhibits the calcium-dependent cysteine proteases, calpain I (µ-calpain) and calpain II (m-calpain), which require micromolar and millimolar calcium concentrations, respectively. Unlike its action on calpains, this 27 amino acid peptide does not inhibit papain (a cysteine protease) or trypsin (a serine protease). Encoded by exon 1B of Ac-calpastatin (184-210), it aligns with a section of inhibitory domain 1, showcasing its specificity and inhibitory function towards calpain enzymes.

Formula: C₁₄₂H₂₃₀N₃₆O₄₄S

Color and Shape: Solid

Molecular weight: 3177.7

Ref: TM-T84437