2-Hydroxyaclacinomycin A, with the CAS number 79127-36-9, is a member of the aclacinomycin family, which are anthracycline antibiotics derived from the bacterium *Micromonospora* species. This compound is characterized by its complex polycyclic structure, which includes a chromophore that contributes to its biological activity. It possesses a hydroxyl group at the 2-position, which is significant for its pharmacological properties. 2-Hydroxyaclacinomycin A exhibits potent antitumor activity, primarily through its ability to intercalate DNA, thereby inhibiting topoisomerase II and disrupting DNA replication and transcription. This mechanism makes it a valuable compound in cancer therapy. Additionally, it may exhibit varying solubility and stability profiles, influencing its bioavailability and therapeutic efficacy. As with many anthracyclines, it may also have associated side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. Overall, 2-hydroxyaclacinomycin A represents an important area of research in the development of effective anticancer agents.

2-hydroxyaclacinomycin A

79127-36-9: 2-Hydroxyaclacinomycin A, with the CAS number 79127-36-9, is a member of the aclacinomycin family, which are anthracycline antibiotics derived from the bacterium *Micromonospora* species. This compound is characterized by its complex polycyclic structure, which includes a chromophore that contributes to its biological activity. It possesses a hydroxyl group at the 2-position, which is significant for its pharmacological properties. 2-Hydroxyaclacinomycin A exhibits potent antitumor activity, primarily through its ability to intercalate DNA, thereby inhibiting topoisomerase II and disrupting DNA replication and transcription. This mechanism makes it a valuable compound in cancer therapy. Additionally, it may exhibit varying solubility and stability profiles, influencing its bioavailability and therapeutic efficacy. As with many anthracyclines, it may also have associated side effects, including cardiotoxicity, which necessitates careful monitoring during treatment. Overall, 2-hydroxyaclacinomycin A represents an important area of research in the development of effective anticancer agents.

<p>2-Hydroxyaclacinomycin A is an anthracycline antibiotic that demonstrates inhibitory activity against leukemia L-1210 cells, with IC50 values for RNA and DNA synthesis of 0.10 μg/mL and 0.95 μg/mL, respectively.</p>

CAS 79127-36-9

2-hydroxyaclacinomycin A

2-Hydroxyaclacinomycin A

Ref: TM-TN10370