CAS 79350-37-1

Cefixime

Description:

Cefixime is a broad-spectrum cephalosporin antibiotic used primarily to treat bacterial infections. It is effective against a variety of gram-positive and gram-negative bacteria, making it useful for conditions such as respiratory tract infections, urinary tract infections, and certain types of gastroenteritis. Cefixime works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. The compound is typically administered orally and is well-absorbed in the gastrointestinal tract, with its bioavailability enhanced by food intake. Cefixime is characterized by its chemical structure, which includes a beta-lactam ring, a key feature of cephalosporins that is crucial for its antibacterial activity. It is generally well-tolerated, but like all antibiotics, it may cause side effects, including gastrointestinal disturbances and allergic reactions in some individuals. Resistance to cefixime can occur, particularly with overuse or misuse of antibiotics, highlighting the importance of appropriate prescribing practices. Overall, cefixime remains a valuable option in the treatment of various bacterial infections.

Formula: C₁₆H₁₅N₅O₇S₂

InChI: InChI=1S/C16H15N5O7S2/c1-2-6-4-29-14-10(13(25)21(14)11(6)15(26)27)19-12(24)9(20-28-3-8(22)23)7-5-30-16(17)18-7/h2,5,10,14H,1,3-4H2,(H2,17,18)(H,19,24)(H,22,23)(H,26,27)/b20-9-/t10-,14-/m1/s1

InChI key: InChIKey=OKBVVJOGVLARMR-QSWIMTSFSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\OCC(O)=O)/C=3N=C(N)SC3)=O)C2=O)(SCC1C=C)[H]

Synonyms:

• (-)-Cefixim
• (6R,7R)-7-(2-(2-Amino-4-thiazolyl)gloxylamido)-8-oxo-3-vinyl-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7(square)-(Z)-(O-(carboxymethyl)oxime)-trihydrate
• (6R,7R)-7-({(2-amino-1,3-thiazol-4-yl)[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-({(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-[(carboxymethoxy)imino]acetyl}amino)-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid trihydrate
• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, [6R-[6α,7α(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-[(carboxymethoxy)imino]acetyl]amino]-3-ethenyl-8-oxo-, (6R,7R)-
• Cefexy
• Cefixime main-ring
• Cefiximine
• Cefixoral
• Cefoceb
• Cefspan
• Ceftas
• Cephoral
• Cl 284635
• Fixitil
• Fk 027
• Fr 17027
• Hifen
• Loprax
• Oroken
• Suprax
• Suprax (antibiotic)
• Taxim-O
• Unixime

Cefixime

CAS: 79350-37-1

Formula: C₁₆H₁₅N₅O₇S₂

Purity: 99%

Color and Shape: Solid

Molecular weight: 453.4496

Ref: IN-DA003AX7

Cefixime

CAS: 79350-37-1

Cefixime is a broad-spectrum third-gen cephalosporin antibiotic, stable against beta-lactamases and more effective on gram-negative bacteria.

Formula: C₁₆H₁₅N₅O₇S₂

Purity: 97.29%

Color and Shape: White To Off White Powder Or Off White Crystal Powder

Molecular weight: 453.45

Ref: TM-T0932

Cefixime-13C-15N2

CAS: 79350-37-1

Formula: C₁₅₁₃CH₁₅N₃₁₅N₂O₇S₂

Molecular weight: 456.42

Ref: 4Z-C-912

Cefixime

CAS: 79350-37-1

Cefixime

Purity: ChP, ≥98%

Molecular weight: 453.45g/mol

Ref: 54-OR1029839

Cefixime

CAS: 79350-37-1

Cefixime

Purity: ≥95%

Molecular weight: 453.45g/mol

Ref: 54-BUP17014

Cefixime

CAS: 79350-37-1

Formula: C₁₆H₁₅N₅O₇S₂

Color and Shape: Off-White Solid

Molecular weight: 453.44

Ref: 4Z-C-911

Cefixime-13C,15N2

Controlled Product

CAS: 79350-37-1

Applications Labelled Cefixime (C242800). Orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Formula: C₁₅₁₃CH₁₅N₃₁₅N₂O₇S₂

Color and Shape: Beige Solid

Molecular weight: 456.43

Ref: TR-C242802

Cefixime

CAS: 79350-37-1

Stability Hygroscopic
Applications Orally active, third generation cephalosporin antibiotic.
References Kamimura, T., et al.: Antimicrob. Agents Chemother., 25, 98 (1984),Yamanaka, H., et al.: J. Antibiot., 38, 1738 (1985), Guay, D.R.P., et al.: Antimicrob. Agents Chemother., 30, 485 (1986),

Formula: C₁₆H₁₅N₅O₇S₂

Color and Shape: Off-White To Light Yellow

Molecular weight: 453.45

Ref: TR-C242800

Cefixime-13C3-15N2

Controlled Product

CAS: 79350-37-1

Formula: C₁₃C₃H₁₅N₃N₂O₇S₂

Color and Shape: Neat

Molecular weight: 607.598

Ref: TR-C242801

Cefixime

CAS: 79350-37-1

Cefixime is a penicillin-binding protein inhibitor that binds to the 50S ribosomal subunit. It is used for the treatment of infectious diseases caused by bacteria. Cefixime has been shown to have an optimum concentration of 2-4 micrograms/mL in human plasma. The oral bioavailability of cefixime is approximately 30% and it has an elimination half-life of 1.5 hours. The drug is metabolized primarily through oxidation by cytochrome P450 enzymes, which are induced by other drugs, such as erythromycin and clarithromycin, or enzyme inducers such as phenobarbital, rifampin, or carbamazepine. Cefixime inhibits bacterial growth through competitive inhibition with penicillin-binding proteins (PBPs), which are required for bacterial cell wall synthesis and protein synthesis.

Formula: C₁₆H₁₅N₅O₇S₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 453.45 g/mol

Ref: 3D-EDA35037