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CAS 79356-08-4

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Maduramicin α

Description:
Maduramicin α is a polyether ionophore antibiotic that is primarily used as a feed additive in veterinary medicine, particularly in poultry and livestock. It is known for its ability to enhance growth rates and improve feed efficiency in animals. Chemically, Maduramicin α is characterized by a complex structure that includes multiple cyclic ether rings, which contribute to its ionophoric properties, allowing it to transport cations across biological membranes. This mechanism of action disrupts cellular ion homeostasis, leading to altered metabolic processes in target organisms. Maduramicin α exhibits a broad spectrum of activity against various Gram-positive bacteria and some protozoa, making it effective in preventing and treating certain infections in livestock. However, its use is regulated due to concerns about potential residues in animal products and the development of antibiotic resistance. As with many ionophores, careful management of dosages is essential to minimize toxicity risks to non-target species and to ensure food safety.
Formula:C47H80O17
InChI:InChI=1S/C47H80O17/c1-23-18-24(2)45(9,51)61-36(23)31-19-32(58-35-20-30(53-10)40(55-12)28(6)57-35)42(59-31)44(8)15-14-33(60-44)43(7)16-17-46(64-43)21-29(48)25(3)37(62-46)26(4)38-41(56-13)39(54-11)27(5)47(52,63-38)22-34(49)50/h23-33,35-42,48,51-52H,14-22H2,1-13H3,(H,49,50)/t23-,24+,25+,26+,27-,28-,29-,30-,31+,32-,33+,35+,36-,37-,38-,39-,40-,41-,42+,43-,44-,45-,46+,47+/m0/s1
InChI key:InChIKey=RWVUEZAROXKXRT-VQLSFVLHSA-N
SMILES:C[C@@]1(O[C@]2(O[C@]([C@@H](C)[C@]3([C@H](OC)[C@@H](OC)[C@H](C)[C@](CC(O)=O)(O)O3)[H])([C@H](C)[C@@H](O)C2)[H])CC1)[C@@]4(O[C@@](C)(CC4)[C@]5([C@@H](O[C@@H]6C[C@H](OC)[C@@H](OC)[C@H](C)O6)C[C@@](O5)([C@]7(O[C@](C)(O)[C@H](C)C[C@@H]7C)[H])[H])[H])[H]
Synonyms:
  • 1,6-Dioxaspiro[4.5]decane, maduramicin α deriv.
  • (29S)-9,13:17,20:21,24-Trianhydro-2,4,8,10,12,14,15,18,19,23,26,27,28,30-tetradecadeoxy-4,8,10,26,28-pentamethyl-16,20-di-C-methyl-5,6-di-O-methyl-22-[(2,6-dideoxy-3,4-di-O-methyl-β-L-arabinopyranosyl)oxy]-L-glycero-L-allo-α-D-allo-L-xylo-α-L-gluco-3,13,29-triacontotriulo-13,16-furanose-3,7:29,25-dipyranosonic acid
  • Antibiotic X 14868A
  • Maduramicin
  • Maduramicin α
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