CAS 796073-69-3

DM4

Description:

DM4, with the CAS number 796073-69-3, is a chemical compound that belongs to a class of substances known for their potential applications in various fields, including medicinal chemistry and materials science. While specific details about its structure and properties may vary, DM4 is typically characterized by its unique molecular framework, which may include functional groups that impart specific reactivity or biological activity. It is often studied for its interactions with biological targets, making it of interest in drug development. Additionally, DM4 may exhibit properties such as solubility in organic solvents, stability under certain conditions, and specific spectral characteristics that can be analyzed using techniques like NMR or mass spectrometry. As with any chemical substance, safety data sheets should be consulted for handling and toxicity information, and its use should comply with relevant regulations and guidelines. Further research and characterization are essential to fully understand its properties and potential applications.

Synonyms:

• Mertansine Impurity 1
• Ravtansine
• Maytansine, N2'-deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-

N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine

CAS: 796073-69-3

Formula: C₃₈H₅₄ClN₃O₁₀S

Purity: 97%

Color and Shape: Solid

Molecular weight: 780.3675

Ref: IN-DA0039AK

DM4

CAS: 796073-69-3

DM4 (Ravtansine) can be used in the preparation of antibody drug conjugate and it is an antitubulin agent. It can inhibit cell division.

Formula: C₃₈H₅₄ClN₃O₁₀S

Purity: 98.15%

Color and Shape: Solid

Molecular weight: 780.37

Ref: TM-T15141

DM4

CAS: 796073-69-3

DM4

Purity: ≥98%

Molecular weight: 780.37g/mol

Ref: 54-BUP04064

Maytansinoid DM4

CAS: 796073-69-3

Formula: C₃₈H₅₄ClN₃O₁₀S

Color and Shape: White To Off-White Solid

Molecular weight: 780.37

Ref: 4Z-M-116002

Maytansinoid DM4-d6

CAS: 796073-69-3

Formula: C₃₈H₄₈D₆ClN₃O₁₀S

Color and Shape: White To Off-White Solid

Molecular weight: 786.41

Ref: 4Z-M-116004

Maytansinoid DM 4

CAS: 796073-69-3

N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine (DMAP) is a structural analogue of maytansinoids that has potent antitumor activity against renal cell cancer. DMAP binds to the active site of wild type enzyme, and inhibits its activity. DMAP also inhibits the activities of other enzymes that are involved in the synthesis of proteins and other cellular components. The inhibition of these enzymes by DMAP leads to tumor cell death. This drug was found to be more cytotoxic at higher doses than the parent compound, maytansinol, which indicates that DMAP has a higher affinity for its target enzyme. The cytotoxicity of this drug is not affected by platinum resistance in ovarian cancer cells or by P-glycoprotein (Pgp) inhibitors such as verapamil and cyclosporin A.

Formula: C₃₈H₅₄ClN₃O₁₀S

Purity: Min. 95%

Color and Shape: Off-White Powder

Molecular weight: 780.37 g/mol

Ref: 3D-FD36534

DM4-d6

Controlled Product

CAS: 796073-69-3

Formula: C₃₈D₆H₄₈ClN₃O₁₀S

Color and Shape: Neat

Molecular weight: 786.404

Ref: TR-D198091

N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine

Controlled Product

CAS: 796073-69-3

Applications N2'-Deacetyl-N2'-(4-mercapto-4-methyl-1-oxopentyl)-maytansine is an intermediate used to prepare semisynthetic maytansine analogs which can be conjugated with antibodies for the targeted treatment of cancer.
References Widdison, W., et al.: J. Med. Chem., 49, 4392 (2006)

Formula: C₃₈H₅₄ClN₃O₁₀S

Color and Shape: Neat

Molecular weight: 780.367

Ref: TR-D198090