CAS 796073-70-6

Maytansine, N2′-deacetyl-N2′-[4-(methyldithio)-1-oxopentyl]-

Description:

Maytansine, N2′-deacetyl-N2′-[4-(methyldithio)-1-oxopentyl]- is a synthetic derivative of maytansine, a potent antitumor agent originally derived from the plant Maytenus serrata. This compound is characterized by its complex structure, which includes a maytansine core modified with a methyldithio group and an oxopentyl side chain. The presence of the methyldithio moiety enhances its biological activity and solubility, making it a subject of interest in cancer research. Maytansine and its derivatives function primarily by inhibiting microtubule assembly, thereby disrupting mitotic processes in rapidly dividing cancer cells. This mechanism of action positions maytansine derivatives as potential candidates for targeted cancer therapies, particularly in the development of antibody-drug conjugates. The compound's stability, solubility, and cytotoxicity are critical characteristics that influence its therapeutic efficacy and safety profile. As research continues, understanding the pharmacokinetics and pharmacodynamics of this compound will be essential for its application in clinical settings.

Formula: C₃₈H₅₄ClN₃O₁₀S₂

InChI: InChI=1S/C38H54ClN3O10S2/c1-21-12-11-13-29(49-9)38(47)20-28(50-36(46)40-38)23(3)34-37(5,52-34)30(51-35(45)24(4)41(6)31(43)15-14-22(2)54-53-10)19-32(44)42(7)26-17-25(16-21)18-27(48-8)33(26)39/h11-13,17-18,22-24,28-30,34,47H,14-16,19-20H2,1-10H3,(H,40,46)/b13-11+,21-12+/t22?,23-,24+,28+,29-,30+,34+,37+,38+/m1/s1

InChI key: InChIKey=YCOIJPSIDUQDNN-UQJMXLCASA-N

SMILES: C[C@]12[C@@](O1)([C@H](C)[C@@]3(C[C@](O)([C@H](OC)/C=C/C=C(\C)/CC4=CC(N(C)C(=O)C[C@@H]2OC([C@@H](N(C(CCC(SSC)C)=O)C)C)=O)=C(Cl)C(OC)=C4)NC(=O)O3)[H])[H]

Synonyms:

• Maytansine, N2′-deacetyl-N2′-[4-(methyldithio)-1-oxopentyl]-

DM3-SMe

CAS: 796073-70-6

Formula: C₃₈H₅₄ClN₃O₁₀S₂

Molecular weight: 812.4325

Ref: IN-DA003PUX

DM3-SMe

CAS: 796073-70-6

DM3-SMe, a maytansine derivative, inhibits tubulin and binds to antibodies. It's cytotoxic, with an IC50 of 0.0011 nM.

Formula: C₃₈H₅₄ClN₃O₁₀S₂

Purity: 98%

Color and Shape: Solid

Molecular weight: 812.43

Ref: TM-T11057

DM3-SMe

CAS: 796073-70-6

Please enquire for more information about DM3-SMe including the price, delivery time and more detailed product information at the technical inquiry form on this page

Formula: C₃₈H₅₄ClN₃O₁₀S₂

Purity: Min. 95%

Molecular weight: 812.4 g/mol

Ref: 3D-WGB07370