CAS 79642-50-5

Disuccinimidyl glutarate

Description:

Disuccinimidyl glutarate (DSG) is a crosslinking agent commonly used in biochemistry and molecular biology for protein and peptide conjugation. It is characterized by its ability to form stable amide bonds between primary amines, making it particularly useful for linking biomolecules such as proteins, antibodies, and nucleic acids. DSG is a homobifunctional crosslinker, meaning it contains two reactive succinimidyl ester groups that can react with amine-containing compounds. The presence of a glutarate spacer provides flexibility, which can enhance the efficiency of crosslinking. DSG is typically soluble in organic solvents and has a relatively low molecular weight, facilitating its use in various applications, including drug delivery systems and the development of biosensors. Its reactivity is influenced by pH and temperature, and it is essential to handle DSG with care due to its potential to react with unintended amine groups, leading to nonspecific crosslinking. Overall, DSG is a valuable tool in the field of chemical biology for creating stable conjugates and studying protein interactions.

Formula: C₁₃H₁₄N₂O₈

InChI: InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2

InChI key: InChIKey=LNQHREYHFRFJAU-UHFFFAOYSA-N

SMILES: O(C(CCCC(ON1C(=O)CCC1=O)=O)=O)N2C(=O)CCC2=O

Synonyms:

• N,N′-Disuccinimidyl glutarate
• DSG Crosslinker
• 2,5-Pyrrolidinedione, 1,1′-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis-
• Pentanedioic acid, 1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester
• Disuccinimidyl glutarate

Disuccinimidyl Glutarate

CAS: 79642-50-5

Formula: C₁₃H₁₄N₂O₈

Purity: >98.0%(T)(HPLC)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 326.26

Ref: 3B-D5445

Disuccinimidyl glutarate, 97%

CAS: 79642-50-5

Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is a homobifunctionla cross-linking reagent, for ex. isolation of the insulin receptor. This Thermo Scientific Chemicals brand product was originally part

Formula: C₁₃H₁₄N₂O₈

Purity: 97%

Color and Shape: White to cream, Crystals or crystalline powder or powder

Molecular weight: 326.26

Ref: 02-H58208

Pentanedioic acid,1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester

CAS: 79642-50-5

Formula: C₁₃H₁₄N₂O₈

Purity: 97%

Color and Shape: Solid

Molecular weight: 326.2589

Ref: IN-DA00514X

Bis(2,5-Dioxopyrrolidin-1-Yl) Glutarate

CAS: 79642-50-5

Bis(2,5-Dioxopyrrolidin-1-Yl) Glutarate

Purity: 97%

Molecular weight: 326.26g/mol

Ref: 54-OR1012410

DSG Crosslinker

CAS: 79642-50-5

DSG Crosslinker

Purity: ≥98%

Molecular weight: 326.26g/mol

Ref: 54-BUP17812

Disuccinimidyl glutarate

CAS: 79642-50-5

Formula: C₁₃H₁₄N₂O₈

Purity: ≥ 97.0%

Color and Shape: White to off-white powder

Molecular weight: 326.26

Ref: 7W-GE2311

DISUCCINIMIDYL GLUTARATE

CAS: 79642-50-5

Formula: C₁₃H₁₄N₂O₈

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 326.261

Ref: 10-F500305

DSG Crosslinker

CAS: 79642-50-5

DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

Formula: C₁₃H₁₄N₂O₈

Purity: 99.46% - 99.89%

Color and Shape: Solid

Molecular weight: 326.26

Ref: TM-T15171

Disuccinimidyl Glutarate

Controlled Product

CAS: 79642-50-5

Applications Disuccinimidyl Glutarate is an amine-reactive, NHS ester-based crosslinker, 7.7 angstrom spacer arm. It has been studied on its polarity influence on lysine side chain selectivity.
References Fiala, J., et al.: J. Proteom, 218, 103716 (2020)

Formula: C₁₃H₁₄N₂O₈

Color and Shape: Neat

Molecular weight: 326.259

Ref: TR-D493560