CAS 79642-50-5: Disuccinimidyl glutarate

Description: Disuccinimidyl glutarate (DSG) is a crosslinking agent commonly used in biochemistry and molecular biology for protein and peptide conjugation. It is characterized by its ability to form stable amide bonds between primary amines, making it particularly useful for linking biomolecules such as proteins, antibodies, and nucleic acids. DSG is a homobifunctional crosslinker, meaning it contains two reactive succinimidyl ester groups that can react with amine-containing compounds. The presence of a glutarate spacer provides flexibility, which can enhance the efficiency of crosslinking. DSG is typically soluble in organic solvents and has a relatively low molecular weight, facilitating its use in various applications, including drug delivery systems and the development of biosensors. Its reactivity is influenced by pH and temperature, and it is essential to handle DSG with care due to its potential to react with unintended amine groups, leading to nonspecific crosslinking. Overall, DSG is a valuable tool in the field of chemical biology for creating stable conjugates and studying protein interactions.

Formula: C₁₃H₁₄N₂O₈

InChI: InChI=1S/C13H14N2O8/c16-8-4-5-9(17)14(8)22-12(20)2-1-3-13(21)23-15-10(18)6-7-11(15)19/h1-7H2

InChI key: InChIKey=LNQHREYHFRFJAU-UHFFFAOYSA-N

SMILES: O=C(ON1C(=O)CCC1=O)CCCC(=O)ON2C(=O)CCC2=O

Synonyms:

• N,N′-Disuccinimidyl glutarate
• DSG Crosslinker
• 2,5-Pyrrolidinedione, 1,1′-[(1,5-dioxo-1,5-pentanediyl)bis(oxy)]bis-
• Pentanedioic acid, 1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester
• Disuccinimidyl glutarate

Disuccinimidyl Glutarate

CAS: 79642-50-5

• Formula: C₁₃H₁₄N₂O₈
• Purity: >98.0%(T)(HPLC)
• Color and Shape: White to Light yellow powder to crystal
• Molecular weight: 326.26

Disuccinimidyl glutarate, 97%

CAS: 79642-50-5

Disuccinimidyl glutarate is used as a membrane-soluble, amine-reactive N-hydroxysuccinamide ester-based homobifunctional crosslinking reagent. It is …

• Formula: C₁₃H₁₄N₂O₈
• Purity: 97%
• Color and Shape: White to cream, Crystals or crystalline powder or powder
• Molecular weight: 326.26

Pentanedioic acid,1,5-bis(2,5-dioxo-1-pyrrolidinyl) ester

CAS: 79642-50-5

• Formula: C₁₃H₁₄N₂O₈
• Purity: 98%
• Color and Shape: Solid
• Molecular weight: 326.2589

Bis(2,5-Dioxopyrrolidin-1-Yl) Glutarate

CAS: 79642-50-5

• Purity: 97%
• Molecular weight: 326.26g/mol

DSG Crosslinker

CAS: 79642-50-5

• Purity: ≥98%
• Molecular weight: 326.26g/mol

Disuccinimidyl glutarate

CAS: 79642-50-5

• Formula: C₁₃H₁₄N₂O₈
• Purity: ≥ 97.0%
• Color and Shape: White to off-white powder
• Molecular weight: 326.26

DISUCCINIMIDYL GLUTARATE

CAS: 79642-50-5

• Purity: 95.0%
• Color and Shape: Solid
• Molecular weight: 326.260986328125

DSG Crosslinker

CAS: 79642-50-5

DSG Crosslinker is a cleavable ADC linker used in antibody-drug conjugates (ADCs) synthesis.

• Formula: C₁₃H₁₄N₂O₈
• Purity: 98.12% - 99.89%
• Color and Shape: Solid
• Molecular weight: 326.26

Disuccinimidyl Glutarate

CAS: 79642-50-5

Applications Disuccinimidyl Glutarate is an amine-reactive, NHS ester-based crosslinker, 7.7 angstrom spacer arm. It has …

• Formula: C₁₃H₁₄N₂O₈
• Color and Shape: Neat
• Molecular weight: 326.259

Di(N-hydroxysuccinimidyl)glutarate

CAS: 79642-50-5

Di(N-hydroxysuccinimidyl)glutarate (DSG) is a cross-linking reagent that is used for the fixation of biological samples. …

• Formula: C₁₃H₁₄N₂O₈
• Purity: Min. 95%
• Color and Shape: Powder
• Molecular weight: 326.26 g/mol