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CAS 796967-16-3

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Linifanib

Description:
Linifanib is a small molecule tyrosine kinase inhibitor primarily developed for the treatment of various cancers, including solid tumors. It targets multiple receptor tyrosine kinases, which play crucial roles in tumor growth, angiogenesis, and metastasis. The chemical structure of Linifanib includes a complex arrangement of aromatic rings and functional groups that contribute to its biological activity. It is typically administered orally and has been studied in clinical trials for its efficacy and safety profile. Linifanib's mechanism of action involves the inhibition of signaling pathways that are essential for cancer cell proliferation and survival. As with many targeted therapies, its use may be associated with specific side effects, which can vary depending on the individual patient and the context of treatment. Overall, Linifanib represents a promising approach in the field of oncology, particularly for patients with tumors that exhibit sensitivity to its mechanism of action.
Formula:C21H18FN5O
InChI:InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)
InChI key:InChIKey=MPVGZUGXCQEXTM-UHFFFAOYSA-N
SMILES:NC=1C2=C(C=CC=C2NN1)C3=CC=C(NC(NC4=C(F)C=CC(C)=C4)=O)C=C3
Synonyms:
  • Abt 869
  • Al 39324
  • Linifanib
  • Linigfanib
  • N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea
  • Rg 3635
  • Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)-
  • 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea
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Found 8 products.