CAS 796967-16-3

Linifanib

Description:

Linifanib is a small molecule tyrosine kinase inhibitor primarily developed for the treatment of various cancers, including solid tumors. It targets multiple receptor tyrosine kinases, which play crucial roles in tumor growth, angiogenesis, and metastasis. The chemical structure of Linifanib includes a complex arrangement of aromatic rings and functional groups that contribute to its biological activity. It is typically administered orally and has been studied in clinical trials for its efficacy and safety profile. Linifanib's mechanism of action involves the inhibition of signaling pathways that are essential for cancer cell proliferation and survival. As with many targeted therapies, its use may be associated with specific side effects, which can vary depending on the individual patient and the context of treatment. Overall, Linifanib represents a promising approach in the field of oncology, particularly for patients with tumors that exhibit sensitivity to its mechanism of action.

Formula: C₂₁H₁₈FN₅O

InChI: InChI=1S/C21H18FN5O/c1-12-5-10-16(22)18(11-12)25-21(28)24-14-8-6-13(7-9-14)15-3-2-4-17-19(15)20(23)27-26-17/h2-11H,1H3,(H3,23,26,27)(H2,24,25,28)

InChI key: InChIKey=MPVGZUGXCQEXTM-UHFFFAOYSA-N

SMILES: NC=1C2=C(C=CC=C2NN1)C3=CC=C(NC(NC4=C(F)C=CC(C)=C4)=O)C=C3

Synonyms:

• Abt 869
• Al 39324
• Linifanib
• Linigfanib
• N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N′-(2-fluoro-5-methylphenyl)urea
• Rg 3635
• Urea, N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)-
• 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea

N-[4-(3-Amino-1H-indazol-4-yl)phenyl]-N'-(2-fluoro-5-methylphenyl)urea

CAS: 796967-16-3

Formula: C₂₁H₁₈FN₅O

Purity: %

Color and Shape: Solid

Molecular weight: 375.3989

Ref: IN-DA0036HT

Linifanib

CAS: 796967-16-3

Linifanib

Purity: ≥98%

Molecular weight: 375.4g/mol

Ref: 54-BUP15482

Linifanib

CAS: 796967-16-3

Formula: C₂₁H₁₈FN₅O

Purity: >95.0%(HPLC)(qNMR)

Color and Shape: White to Light yellow powder to crystal

Molecular weight: 375.41

Ref: 3B-L0473

1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea

CAS: 796967-16-3

1-[4-(3-Amino-1H-indazol-4-yl)phenyl]-3-(2-fluoro-5-methylphenyl)urea

Purity: 98%

Molecular weight: 375.40g/mol

Ref: 54-PC402063

Linifanib

CAS: 796967-16-3

Linifanib (AL-39324) (ABT-869) is a novel, potent ATP-competitive VEGFR/PDGFR inhibitor for KDR (IC50: 4 nM), CSF-1R (IC50: 3 nM), Flt-1/3 (IC50: 3/4 nM) and

Formula: C₂₁H₁₈FN₅O

Purity: 98% - 98.24%

Color and Shape: Solid

Molecular weight: 375.4

Ref: TM-T2514

Linifanib

CAS: 796967-16-3

Ref: 7W-GW0425

1-(4-(3-Amino-1H-indazol-4-yl)phenyl)-3-(2-fluoro-5-methylphenyl)urea

CAS: 796967-16-3

Purity: 95.0%

Color and Shape: Solid

Molecular weight: 375.4070129394531

Ref: 10-F432317

Linifanib

CAS: 796967-16-3

Applications Linifanib (ABT 869) is an oral tyrosine kinase inhibitor with antineoplasic activity. As a dual inhibitor, Linifanib, is being tested on several different cancers.
References Haddley, K., et al.: Drugs of the Future, 35, 106 (2010), Cheng, A., et al.: J. Med. Chem., 53, 4502 (2010),

Formula: C₂₁H₁₈FN₅O

Color and Shape: Neat

Molecular weight: 375.40

Ref: TR-L466450