CAS 79781-00-3

Bulaquine

Description:

Bulaquine, with the CAS number 79781-00-3, is an antimalarial compound that belongs to the class of 4-aminoquinolines. It is primarily characterized by its ability to inhibit the growth of Plasmodium species, the parasites responsible for malaria. Bulaquine exhibits a mechanism of action similar to that of chloroquine, interfering with the parasite's ability to detoxify heme, which is a byproduct of hemoglobin digestion. This leads to the accumulation of toxic heme within the parasite, ultimately resulting in its death. The compound is typically administered in a specific dosage regimen to maximize its efficacy while minimizing potential side effects. Bulaquine's pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for its therapeutic effectiveness. While it has shown promise in clinical settings, its use may be limited by the development of resistance among malaria parasites. Ongoing research continues to explore its potential in combination therapies and its effectiveness against various malaria strains.

Formula: C₂₁H₂₇N₃O₃

InChI: InChI=1/C21H27N3O3/c1-14(6-4-9-22-15(2)18-8-11-27-21(18)25)24-19-13-17(26-3)12-16-7-5-10-23-20(16)19/h5,7,10,12-14,22,24H,4,6,8-9,11H2,1-3H3/b18-15+

InChI key: InChIKey=ADCOUXIGWFEYJP-UHFFFAOYSA-N

SMILES: N(C(CCCNC(C)=C1C(=O)OCC1)C)C=2C3=C(C=C(OC)C2)C=CC=N3

Synonyms:

• (3E)-3-[1-({4-[(6-methoxyquinolin-8-yl)amino]pentyl}amino)ethylidene]dihydrofuran-2(3H)-one
• 1-[4,5-Dihydro-2-[4-(6-methoxyquinolin-8-ylamino)pentylamino]furan-3-yl]ethanone
• 2(3H)-Furanone, dihydro-3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-
• 3-[1-[[4-[(6-Methoxy-8-quinolyl)amino]pentyl]amino]ethylidene]dihydro-2(3H)-furanone
• 80/53
• Aablaquine
• Bulaquine
• Cdri-80/53
• Compound 80/53
• Dihydro-3-[1-[[4-[(6-methoxy-8-quinolinyl)amino]pentyl]amino]ethylidene]-2(3H)-furanone
• Elubaquine
• 1-[4,5-Dihydro-2-[[4-[(6-methoxyquinoline-8-yl)amino]pentyl]amino]furan-3-yl]ethanone

Bulaquine

Controlled Product

CAS: 79781-00-3

Applications Bulaquine is anti-malarial drug.
References Vale, N., et al.: Eur. J. Med. Chem., 44, 937 (2009); Delves, M., et al.: PLOS Med., 10, 1001169 (2012); Kulkarni, S.: Eur. J. Pharm. Sci., 2, 986 (2015);

Formula: C₂₁H₂₇N₃O₃

Color and Shape: Neat

Molecular weight: 369.457

Ref: TR-B694880

Bulaquine

CAS: 79781-00-3

Bulaquine, a 8-aminoquinoline derivative, targets liver stage of P. falciparum and dormant P. vivax/ovale.

Formula: C₂₁H₂₇N₃O₃

Color and Shape: Solid

Molecular weight: 369.46

Ref: TM-T30612