CAS 79794-75-5

Loratadine

Description:

Loratadine is a second-generation antihistamine commonly used to relieve allergy symptoms such as runny nose, sneezing, and itchy eyes. It is characterized by its selective antagonism of peripheral H1 receptors, which helps to minimize common side effects associated with first-generation antihistamines, such as sedation. Loratadine is a white to off-white crystalline powder that is practically insoluble in water but soluble in organic solvents like ethanol and methanol. Its chemical formula is C22H23ClN2O2, and it has a molecular weight of approximately 382.88 g/mol. Loratadine is often administered orally and has a long duration of action, allowing for once-daily dosing. It is metabolized in the liver to its active metabolite, desloratadine, which contributes to its antihistaminic effects. Due to its low penetration of the blood-brain barrier, loratadine is less likely to cause drowsiness compared to older antihistamines, making it a preferred choice for individuals needing relief from allergic symptoms without sedation.

Formula: C₂₂H₂₃ClN₂O₂

InChI: InChI=1S/C22H23ClN2O2/c1-2-27-22(26)25-12-9-15(10-13-25)20-19-8-7-18(23)14-17(19)6-5-16-4-3-11-24-21(16)20/h3-4,7-8,11,14H,2,5-6,9-10,12-13H2,1H3

InChI key: InChIKey=JCCNYMKQOSZNPW-UHFFFAOYSA-N

SMILES: ClC=1C=C2C(C(C=3C(CC2)=CC=CN3)=C4CCN(C(OCC)=O)CC4)=CC1

Synonyms:

• 1-Piperidinecarboxylic acid, 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-, ethyl ester
• 11H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 1-piperidinecarboxylic acid deriv.
• 4-(8-Chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene-1-piperidinecarboxylic acid ethyl ester
• Alavert
• Anhissen
• Bonalerg
• Civeran
• Claratyne
• Claritin
• Claritine
• Clarityn
• Clarityne
• Clarotadin
• Cronopen
• Erolin
• Ethyl 4-(8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidinecarboxylate
• Flonidan
• Fristamin
• Histaloran
• Klarifer
• Klaritin
• Lertamine
• Lisino
• Lomilan
• Loracert
• Loradex
• Loranox
• Lorastine
• Loratidine
• Loratyne
• Lorfast
• Lowadina
• Optimin
• Polaratyne
• Pylor
• Restamine
• Sch 29851
• Sensibit
• Sohotin
• Symphoral
• Tadine
• Velodan
• Zeos

Desloratadine EP Impurity C

CAS: 79794-75-5

Formula: C₂₂H₂₃ClN₂O₂

Molecular weight: 382.88

Ref: ST-EA-CP-D15003

Loratadine - Bio-X ™

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.Loratadine is part of our Bio-X ™ Range. These products are aimed at life science researchers who need high quality ready to use products for assay development, screening or other R&D work. With a solubility datasheet and convenient vials, all of our Bio-X ™ products are in stock across our global warehouses for rapid delivery and ease of use.

Formula: C₂₂H₂₃ClN₂O₂

Purity: Min. 95%

Color and Shape: Powder

Molecular weight: 382.88 g/mol

Ref: 3D-BL164637

Loratadine

CAS: 79794-75-5

Loratadine is a non-sedating, inverse agonist antihistamine used for the treatment of allergic rhinitis, an IgE (immunoglobulin E) mediated disease. Loratadine binds to histamine H1 receptors, preventing histamine from binding and causing an allergic reaction.It has been found to inhibit the release of eosinophil cationic protein by acting on different components of allergic inflammation, in particular in the modulation of ICAM-1 expression on nasal epithelial cells as a mechanism of protective for the epithelium, and therefore, the damage of mucosa is reduced. In recent studies, it was found that loratadine is a potent HR1 antagonist with in vitro inhbitory effect on human mast-cell lines, HMC-1 (from mast cell leukaemia) with an IC50 between 10 and 50 μM.

Formula: C₂₂H₂₃ClN₂O₂

Purity: 98.5 To 101.0%

Color and Shape: Powder

Molecular weight: 382.88 g/mol

Ref: 3D-FL24933

11-(N-Hydroxy) Loratadine 1-Oxide

Controlled Product

CAS: 79794-75-5

Formula: C₁₉H₁₉ClN₂O₂

Color and Shape: Neat

Molecular weight: 342.819

Ref: TR-H947746