CAS 79831-76-8

(+)-Castanospermine

Description:

(+)-Castanospermine is a naturally occurring alkaloid derived from the seeds of the Australian tree Castanospermum australe. It is known for its structural similarity to glucose and is classified as a potent inhibitor of certain glycosidases, particularly α-glucosidases. This characteristic makes it of interest in biochemical research and potential therapeutic applications, particularly in the context of viral infections and diabetes management. The compound exhibits a specific stereochemistry, which contributes to its biological activity. (+)-Castanospermine is typically a white to off-white crystalline solid, soluble in water and various organic solvents. Its molecular formula reflects a complex structure that includes multiple hydroxyl groups, enhancing its reactivity and interaction with biological macromolecules. Due to its biological significance, it has been studied for its potential role in modulating glycoprotein synthesis and its implications in drug development. However, like many alkaloids, it may also exhibit toxicity at higher concentrations, necessitating careful handling and dosage considerations in research and therapeutic contexts.

Formula: C₈H₁₅NO₄

InChI: InChI=1/C8H15NO4/c10-4-1-2-9-3-5(11)7(12)8(13)6(4)9/h4-8,10-13H,1-3H2/t4-,5?,6+,7+,8?/m0/s1

InChI key: InChIKey=JDVVGAQPNNXQDW-TVNFTVLESA-N

SMILES: O[C@@H]1[C@@]2(N(C[C@H](O)[C@H]1O)CC[C@@H]2O)[H]

Synonyms:

• (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine
• (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol
• (1S,6S,7R,8R,8aR)-octahydroindolizine-1,6,7,8-tetrol
• (1S,7R,8aR)-octahydroindolizine-1,6,7,8-tetrol
• 1,6,7,8-Indolizinetetrol, octahydro-, (1S,6S,7R,8R,8aR)-
• 1,6,7,8-Indolizinetetrol, octahydro-, [1S-(1α,6β,7α,8β,8aβ)]-
• Castanospermine
• Castanospermine Castanospermum australe seeds
• Castanospermine From Castanospermum*Australe Seed
• NSC 614552
• Octahydroindolizine-1,6,7,8-Tetrol
• (1S,6S,7R,8AR)-TETRAHYDROXYOCTAHYDROINDOLIZINE
• (1S,6S,7R,8R,8Ar)-Indolizidine-1,6,7,8-Tetrol /(1S,6S,7R,8R,8aR)-1,2,3,5,6,7,8,8a-Octahydroindolizine-1,6,7,8-Tetrol
• (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyindolizidine 98%
• 1,6,7,8-indolizinetetrol,octahydro-,(1s-(1-alpha,6-beta,7-alpha,8-beta,8a-bet
• (8aα)-Octahydroindolizine-1β,6α,7β,8α-tetrol
• (1s,6s,7r,8r,8ar)-1,6,7,8-tetrahydroxyoctahydroindolizidine
• 1,6,7,8-TETRAHYDROXYOCTAHYDROINDOLIZINE
• (1S,6S,7R,8R,8AR)-1,6,7,8-TETRAHYDROXYOCTAHYDROINDOLIZINE
• octahydro-1,6,7,8-indolizinetetrol(1s-(1-alpha,6-beta,7-alpha,8-beta,8a-beta
• CastanosperMin
• CASTANOSPERMINE, CASTANOSPERMUM AUSTRALE
• Castanospermine, Castanospermum australe - CAS 79831-76-8 - Calbiochem
• (1S,6S,7R,8R,8aR)-Octahydroindolizine-1,6,7,8-tetraol
• [1S-(1alpha,6beta,7alpha,8beta,8alphabeta)]-Octahydro-1,6,7,8-indolizinetetrol
• (3S,4R,5R,6R,7S)-1-Azabicyclo[4.3.0]nonane-3,4,5,7-tetrol
• Castanospermine from Castanospermum austral
• 1,6,7,8-Tetrahydroxyoctahydroindolizine, Castanospermine, (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol, (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine
• [1S-(1α,6β,7α,8β,8aβ)]-Octahydro-1,6,7,8-indolizinetetrol
• [1S-(1A,6B,7A,8B,8A-BETA)]-OCTAHYDRO-1,6,7,8-INDOLIZINETETROL
• Castanospermine ,98%
• (1S,6S,7R,8R,8aR)-2,3,4,5,6,7,8,8a-octahydro-1H-indolizin-4-ium-1,6,7,8-tetrol
• (1S,6S,7R,8R,8aR)-1,6,7,8-Tetrahydroxyoctahydroindolizidine, (1S,6S,7R,8R,8aR)-Octahydro-1,6,7,8-indolizinetetrol
• (1S,6S,7R,8R,8AR)-1,6,7,8-TETRAHYDROXY-&
• 7,8-indolizinetetrol,octahydro-,(1s,6s,7r,8r,8ar)-6

Castanospermine, 99%

CAS: 79831-76-8

Potent alpha and beta-glucosidase inhibitor

Formula: C₈H₁₅NO₄

Purity: 99%

Molecular weight: 189.21

Ref: 02-J61071

(1S,6S,7R,8R,8aR)-octahydroindolizine-1,6,7,8-tetrol

CAS: 79831-76-8

Formula: C₈H₁₅NO₄

Purity: 98%

Color and Shape: Solid

Molecular weight: 189.2090

Ref: IN-DA003OPW

Castanospermine

CAS: 79831-76-8

Castanospermine

Purity: ≥95%

Molecular weight: 189.21g/mol

Ref: 54-BUP16381

Castanospermine from Castanospermum austral

CAS: 79831-76-8

Castanospermine from Castanospermum austral

Formula: C₈H₁₅NO₄

Purity: By hplc: 100% (Typical Value in Batch COA)

Color and Shape: white powder

Molecular weight: 189.21g/mol

Ref: 54-BIC0126

Castanospermine

CAS: 79831-76-8

Castanospermine (1,6,7,8-Tetrahydroxyoctahydroindolizine) is a natural compound that inhibits α- and β-glucosidases, especially glucosidase l.

Formula: C₈H₁₅NO₄

Purity: 99.74% - 99.93%

Color and Shape: White Crystalline Solid

Molecular weight: 189.21

Ref: TM-TQ0308

Castanospermine

CAS: 79831-76-8

Formula: C₈H₁₅NO₄

Molecular weight: 189.21

Ref: 7W-GP5690

Castanospermine

Controlled Product

CAS: 79831-76-8

Applications Castanospermine is a plant alkaloid shown to be a potent inhibitor of lysosomal a-or beta- glucosidase. It also inhibits mammalian glucosidase 1 and beta-mannosidase from sweet almonds and fungal beta-xylosidase.
References Arch. Biochem. Biophys., 221, 593 (1983), Clin. Biochem., 17, 3 (1984), Trends Bio. Sci., 9, 32, (1984), J. Biol. Chem., 260, 15873-15879 (1985), FEBS, 1985, 28 (1986)

Formula: C₈H₁₅NO₄

Color and Shape: Off-White

Molecular weight: 189.21

Ref: TR-C185000

Castanospermine

CAS: 79831-76-8

Plant alkaloid and inhibitor of α- and β-glucosidases. It has anti-diabetic potential since its inhibitory activity on α-glucosidases helps control the postprandial blood glucose levels and supresses hyperglycemia. The compound exhibits anti-viral activity against Dengue, Influenza, HIV and Herpes Simplex viruses thanks to its ability to interfere with folding of viral structural glycoproteins.

Formula: C₈H₁₅NO₄

Purity: Min. 95 Area-%

Color and Shape: White Powder

Molecular weight: 189.2 g/mol

Ref: 3D-MC08277

(1S,6S,7R,8R,8aR)-Octahydroindolizine-1,6,7,8-tetraol

CAS: 79831-76-8

Purity: 98%

Molecular weight: 189.2109985

Ref: 10-F869935