CAS 79950-65-5

Boc-L-His(Bom)-OH

Description:

Boc-L-His(Bom)-OH, with the CAS number 79950-65-5, is a protected form of the amino acid histidine, specifically designed for use in peptide synthesis. The "Boc" (tert-butyloxycarbonyl) group serves as a protective group for the amino functionality, allowing for selective reactions without interference from the amine. The "Bom" (benzyl ether) group protects the hydroxyl side chain of histidine, enhancing the stability and reactivity of the molecule during synthesis. This compound is typically used in the preparation of peptides where the preservation of the histidine residue's reactivity is crucial. It is characterized by its solid state at room temperature and is soluble in organic solvents such as dichloromethane and dimethylformamide. The presence of the Boc and Bom groups makes it a valuable intermediate in organic synthesis, particularly in the pharmaceutical and biochemistry fields, where precise control over amino acid functionality is essential. Proper handling and storage conditions are necessary to maintain its stability and reactivity.

Formula: C₁₉H₂₅N₃O₅

InChI: InChI=1/C19H25N3O5/c1-19(2,3)27-18(25)21-16(17(23)24)9-15-10-20-12-22(15)13-26-11-14-7-5-4-6-8-14/h4-8,10,12,16H,9,11,13H2,1-3H3,(H,21,25)(H,23,24)/t16-/m0/s1

SMILES: CC(C)(C)OC(=N[C@@H](Cc1cncn1COCc1ccccc1)C(=O)O)O

Synonyms:

• Boc-His(Bom)-OH
• N(alpha)-boc-N(im)-benzyloxymethoxy-L-histidine monohydr
• 3-[(benzyloxy)methyl]-N-(tert-butoxycarbonyl)-L-histidine
• N-Boc-N'-benzyloxymethyl-L-histidine
• N-tert-Butyloxycarbonyl-N'-benzyloxymethyl-L-histidine

Boc-His(3-Bom)-OH

CAS: 79950-65-5

A protected histidine derivative for Boc-SPPS. Boc-His(Bom)-OH can be coupled with minimal concomitant racemization. As the cleavage of His(Bom) yields HCHO as by-product, scavengers reacting with formaldehyde have to be included in the cleavage system.

Formula: C₁₉H₂₅N₃O₅

Purity: > 99%

Color and Shape: White

Molecular weight: 375.43

Ref: 01-4006621

Boc-L-His(Bom)-OH

CAS: 79950-65-5

Formula: C₁₉H₂₅N₃O₅

Purity: 97%

Color and Shape: Solid

Molecular weight: 375.4189

Ref: IN-DA003OH1

Boc-His(3-Bom)-OH

CAS: 79950-65-5

Molecular weight: 375.42

Ref: 7W-GM6458

N-Boc-3-Benzyloxymethyl-L-Histidine

CAS: 79950-65-5

N-Boc-3-Benzyloxymethyl-L-Histidine

Purity: 98%

Molecular weight: 375.42g/mol

Ref: 54-OR1014286

Boc-His(Bom)-OH

CAS: 79950-65-5

M03288 - Boc-His(Bom)-OH

Formula: C₁₉H₂₅N₃O₅

Purity: 97%

Color and Shape: Solid, White powder

Molecular weight: 375.425

Ref: 10-M03288