CAS 79952-44-6

Epilovastatin

Description:

Epilovastatin, with the CAS number 79952-44-6, is a synthetic compound that belongs to the class of statins, which are primarily used for their cholesterol-lowering properties. It functions by inhibiting the enzyme HMG-CoA reductase, a key player in the biosynthesis of cholesterol in the liver. This action helps to reduce levels of low-density lipoprotein (LDL) cholesterol and triglycerides while potentially increasing high-density lipoprotein (HDL) cholesterol. Epilovastatin is characterized by its specific chemical structure, which includes a lactone ring and various functional groups that contribute to its biological activity. It is typically administered orally and has been studied for its efficacy in managing hyperlipidemia and reducing cardiovascular risk. As with other statins, potential side effects may include muscle pain, liver enzyme alterations, and gastrointestinal disturbances. Its pharmacokinetics, including absorption, metabolism, and excretion, are important for determining dosing regimens and understanding its interactions with other medications.

Formula: C₂₄H₃₆O₅

InChI: InChI=1/C24H36O5/c1-5-15(3)24(27)29-21-11-14(2)10-17-7-6-16(4)20(23(17)21)9-8-19-12-18(25)13-22(26)28-19/h6-7,10,14-16,18-21,23,25H,5,8-9,11-13H2,1-4H3/t14?,15?,16-,18+,19+,20-,21?,23-/m0/s1

InChI key: InChIKey=PCZOHLXUXFIOCF-YPQFMRJXSA-N

SMILES: O(C([C@@H](CC)C)=O)[C@@H]1[C@]2(C(C=C[C@H](C)[C@@H]2CC[C@@H]3C[C@@H](O)CC(=O)O3)=C[C@H](C)C1)[H]

Synonyms:

• Epilovastatin
• Butanoic acid, 2-methyl-, (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester, (2R)-
• Butanoic acid, 2-methyl-, 1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-(tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl)ethyl]-1-naphthalenyl ester, [1S-[1α(S*),3α,7β,8β(2S*,4S*),8aβ]]-
• Lovastatin epi-Isomer
• Simvastatin EP Impurity F/ Simvastatin Related Compound F (epi-Lovastatin/ Lovastatin epimer)
• Epilovastatin, 10 - 15% isoMers
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate
• Epi Lovastatin
• (1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-H
• Simvastatin Impurity 6（EP-F）
• (R)-(1S,3R,7S,8S,8aR)-8-(2-((2R,4R)-4-hydroxy-6-oxotetrahydro-2H-pyran-2-yl)ethyl)-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl 2-methylbutanoate
• Simvastatin EP Impurity F (epi-Lovastatin)
• Epilovastatin, 95%, 10 - 15% isomers
• (2R)-2-Methylbutanoic acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl ester
• Simvastatin EP Impurity
• Simvastatin EP Impurity F (epi-Lovastatin)/(2R)-2-Methylbutanoic Acid (1S,3R,7S,8S,8aR)-1,2,3,7,8,8a-Hexahydro-3,7-dimethyl-8-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1-naphthalenyl
• Simvastatin Impurity 6(Simvastatin EP Impurity F)

Epi Lovastatin ((1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-methylbutanoate)

CAS: 79952-44-6

Lactones, nesoi

Formula: C₂₄H₃₆O₅

Color and Shape: White Powder

Molecular weight: 404.25627

Ref: 45-1A10320

Simvastatin EP Impurity F (epi-Lovastatin)

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Color and Shape: White To Off-White Solid

Molecular weight: 404.55

Ref: 4Z-S-128

(1S,3R,7S,8S,8aR)-8-[2-[(2R,4R)-4-Hydroxy-6-oxotetrahydro-2H-pyran-2-yl]ethyl]-3,7-dimethyl-1,2,3,7,8,8a-hexahydronaphthalen-1-yl (2R)-2-Methylbutanoate (Epilovastatin)

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Color and Shape: Neat

Molecular weight: 404.54

Ref: 86-MM0158.06

Epi Lovastatin

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Molecular weight: 404.5

Ref: ST-EA-CP-L76020

Simvastatin EP Impurity F

CAS: 79952-44-6

Formula: C₂₄H₃₆O₅

Molecular weight: 404.55

Ref: ST-EA-CP-S4006

Epi Lovastatin

Controlled Product

CAS: 79952-44-6

Impurity Simvastatin EP Impurity F
Applications Epi Lovastatin (Simvastatin EP Impurity F) is a Lovastatin impurity; an antihypercholesterolemic compound.
References Hoffman, W.F., et al.: J. Med. Chem., 29, 849 (1986),

Formula: C₂₄H₃₆O₅

Color and Shape: Neat

Molecular weight: 404.54

Ref: TR-E588530

Epi lovastatin

CAS: 79952-44-6

Lovastatin is a cholesterol-lowering drug that acts by inhibiting the enzyme HMG-CoA reductase. It is also used to prevent organ rejection after a liver transplant, and has been shown to have anti-aging effects. Lovastatin has been shown to reduce serum cholesterol levels, which may be due to its ability to inhibit cellular proliferation in rat hepatocytes. This drug has been shown to have an effect on DNA damage and post-translational modification of proteins, as well as on health care foods. Lovastatin is a member of the statins family of drugs, which are all natural products isolated from fungi or bacteria. The active form of lovastatin is made in the laboratory by chemical synthesis, using recombinant DNA technology. The recombinant gene encoding lovastatin was cloned into an expression vector and expressed in Escherichia coli cells (E.M.).

Formula: C₂₄H₃₆O₅

Purity: Min. 95%

Molecular weight: 404.54 g/mol

Ref: 3D-IE22709