CAS 80054-30-4

para-Topolin

Controlled Product

CAS: 80054-30-4

Applications para-Topolin can be used for biological study for evaluation of antioxidant activity and capacity of some natural N6-substituted adenine derivatives (cytokinins) by fluorimetric and spectrophotometric assays.
References Brizzolari, A., et al.: J. Chromatogr. B., 1019, 164-168 (2016)

Formula: C₁₂H₁₁N₅O

Color and Shape: Neat

Molecular weight: 241.25

Ref: TR-T540300

p-Topolin

CAS: 80054-30-4

P-topolin is a potent inhibitor of the P-glycoprotein (P-gp) transporter. This protein is responsible for drug efflux and is overexpressed in cancers such as cervical cancer. Inhibition of P-gp by p-topolin leads to increased accumulation of cytotoxic drugs in tumor cells, inhibiting their growth and proliferation. P-topolin also has anti-inflammatory properties that are due to its inhibition of the production of inflammatory cytokines, such as gamma-aminobutyric acid, prostaglandins and leukotrienes. The compound has been shown to have no effects on locomotor activity or body weight in mice at doses up to 1000 mg/kg. P-topolin also has a high affinity for the GABA receptor and inhibits its response to GABA stimulation by reducing the binding affinity for GABA at the receptor site.

Formula: C₁₂H₁₁N₅O

Purity: 95%Min

Color and Shape: Powder

Molecular weight: 241.25 g/mol

Ref: 3D-FT30290