CAS 801-52-5

Porfiromycin

Description:

Porfiromycin is an antibiotic compound that belongs to the class of macrolide antibiotics. It is derived from the fermentation of certain strains of Streptomyces bacteria. The chemical structure of porfiromycin features a large lactone ring, which is characteristic of macrolides, and it possesses various functional groups that contribute to its biological activity. This compound exhibits antibacterial properties, particularly against Gram-positive bacteria, and has been studied for its potential use in treating various infections. Porfiromycin's mechanism of action involves inhibiting bacterial protein synthesis, which ultimately leads to the cessation of bacterial growth. Additionally, it has shown some antitumor activity, making it of interest in cancer research. The substance is typically administered in a clinical setting, and its pharmacokinetics, including absorption, distribution, metabolism, and excretion, are crucial for determining its therapeutic efficacy and safety profile. As with many antibiotics, the emergence of resistance is a concern, necessitating ongoing research into its effectiveness and potential alternatives.

Formula: C₁₆H₂₀N₄O₅

InChI: InChI=1S/C16H20N4O5/c1-6-10(17)13(22)9-7(5-25-15(18)23)16(24-3)14-8(19(14)2)4-20(16)11(9)12(6)21/h7-8,14H,4-5,17H2,1-3H3,(H2,18,23)/t7-,8+,14+,16-,19?/m1/s1

InChI key: InChIKey=HRHKSTOGXBBQCB-VFWICMBZSA-N

SMILES: O(C)[C@]12N(C3=C([C@H]1COC(N)=O)C(=O)C(N)=C(C)C3=O)C[C@]4([C@@]2(N4C)[H])[H]

Synonyms:

• (1aS,8S,8aR,8bS)-6-Amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethylazirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione
• (6-Amino-8A-Methoxy-1,5-Dimethyl-4,7-Dioxo-1,1A,2,4,7,8,8A,8B-Octahydroazireno[2',3':3,4]Pyrrolo[1,2-A]Indol-8-Yl)Methyl Carbamate
• 6-Amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethylazirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione carbamate (ester)
• Ai3-50825
• Azirino(2',3':3,4)pyrrolo(1,2-a)-indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-
• Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a- methoxy-1,5-dimethyl-, carbamate (ester) (8CI)
• Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-, carbamate (ester)
• Azirino(2',3':3,4)pyrrolo(1,2-a)indole-4,7-dione, 6-amino-8-(((aminocarbonyl)oxy)methyl)-1,1a,2,8,8a,8b- hexahydro-8a-methoxy-1,5-dimethyl-,(1aR-(1aalpha,8beta,8aalpha,8balpha))- (9CI)
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-1,1a,2,8,8a,8b-hexahydro-8-(hydroxymethyl)-8a-methoxy-1,5-dimethyl-, carbamate (ester)
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, (1aS,8S,8aR,8bS)-
• Azirino[2′,3′:3,4]pyrrolo[1,2-a]indole-4,7-dione, 6-amino-8-[[(aminocarbonyl)oxy]methyl]-1,1a,2,8,8a,8b-hexahydro-8a-methoxy-1,5-dimethyl-, [1aS-(1aα,8β,8aα,8bα)]-
• Ent-50825
• Methyl mitomycin C
• Methylmitomycin
• Mitomycin C, N-methyl-
• N-Methylmitomycin C
• Nci 56410
• Nsc 56410
• Porfiromicina
• Porfiromicina [INN-Spanish]
• Porfiromycin [USAN:INN:BAN]
• Porfiromycine
• Porfiromycine [INN-French]
• Porfiromycinum
• Porfiromycinum [INN-Latin]
• Porphyromycin
• Regamycin
• U-14743
• Unii-H1Wk901Oa6
• [(1aS,8S,8aR,8bS)-6-amino-8a-methoxy-1,5-dimethyl-4,7-dioxo-1,1a,2,4,7,8,8a,8b-octahydroazireno[2',3':3,4]pyrrolo[1,2-a]indol-8-yl]methyl carbamate

Porfiromycin

Controlled Product

CAS: 801-52-5

Applications Antibiotic substance isolated from a Streptomyces ardus fermentation broth. Antibacterial; antineoplastic.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tannock, I., et al.: Clin. Cancer Res., 8, 878 (2002), Cummings, J., et al.: Br. J. Cancer, 92, 532 (2005), Ivascu, A., et al.: J. Biomol. Screen, 11, 922 (2006),

Formula: C₁₆H₂₀N₄O₅

Color and Shape: Purple To Black

Molecular weight: 348.35

Ref: TR-P689450

Porfiromycin

CAS: 801-52-5

Porfiromycin is an antineoplastic antibiotic with action on DNA alkylation and cross-linking and is used for research on cancer treatment, particularly for hypoxic tumors.

Formula: C₁₆H₂₀N₄O₅

Purity: Min. 95 Area-%

Color and Shape: Powder

Molecular weight: 348.35 g/mol

Ref: 3D-AP27106

Porfiromycin

CAS: 801-52-5

Porfiromycin, a mitomycin C derivative from Streptomyces, alkylates DNA and targets hypoxic cells.

Formula: C₁₆H₂₀N₄O₅

Color and Shape: Solid

Molecular weight: 348.35

Ref: TM-T68675