CAS 80115-95-3

N-acetyl-leukotriene E4

Description:

N-acetyl-leukotriene E4 (N-Acetyl-LTE4) is a derivative of leukotriene E4, a potent lipid mediator involved in inflammatory responses and various physiological processes. This compound is characterized by its role in the immune system, particularly in bronchoconstriction and the modulation of immune cell activity. N-acetyl-leukotriene E4 is known for its increased stability compared to its parent compound, which enhances its potential for therapeutic applications. It is typically synthesized through acetylation of leukotriene E4, resulting in a modification that can influence its biological activity and receptor interactions. The substance is of interest in research related to asthma, allergic reactions, and other inflammatory conditions. Its chemical structure includes a series of conjugated double bonds and functional groups that contribute to its reactivity and biological effects. As with many leukotrienes, N-acetyl-leukotriene E4 is studied for its potential role in drug development aimed at managing inflammatory diseases.

Formula: C₂₅H₃₉NO₆S

InChI: InChI=1/C25H39NO6S/c1-3-4-5-6-7-8-9-10-11-12-13-14-17-23(22(28)16-15-18-24(29)30)33-19-21(25(31)32)26-20(2)27/h7-8,10-14,17,21-23,28H,3-6,9,15-16,18-19H2,1-2H3,(H,26,27)(H,29,30)(H,31,32)/b8-7+,11-10+,13-12+,17-14+/t21?,22-,23+/m0/s1

InChI key: InChIKey=BGGYAYMMFYBWEX-UHFFFAOYSA-N

SMILES: C(SCC(NC(C)=O)C(O)=O)(C(CCCC(O)=O)O)C=CC=CC=CCC=CCCCCC

Synonyms:

• (5S,6R,7E,9E,11E,14E)-6-{[2-(acetylamino)-2-carboxyethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
• (5S,6R,7E,9E,11Z,14Z)-6-[[(2R)-2-(Acetylamino)-2-carboxyethyl]thio]-5-hydroxy-7,9,11,14-eicosatetraenoic acid
• (5S,6R,7E,9E,11Z,14Z)-6-{[2-(acetylamino)-2-carboxyethyl]sulfanyl}-5-hydroxyicosa-7,9,11,14-tetraenoic acid
• 5-Hydroxy-6-S-(2-acetamido-3-thiopropionyl)-7,9,11,14-eicosatetraenoic acid
• 7,9,11,14-Eicosatetraenoic acid, 6-((2-(acetylamino)-2-carboxyethyl)thio)-5-hydroxy-, (5S-(5R*,6S*(S*),7E,9E,11Z,14Z))-
• 7,9,11,14-Eicosatetraenoic acid, 6-[[(2R)-2-(acetylamino)-2-carboxyethyl]thio]-5-hydroxy-, (5S,6R,7E,9E,11Z,14Z)-
• N-Acetyl-LTE₄
• N-Acetylleukotriene E4
• N-Acetylleukotriene E₄
• NA-Lte4
• N-Acetyl-LTE4
• leukotriene E4, N-acetyl-
• N-AC-LTE4
• 5S-HYDROXY-6R-(S-(N-ACETYL)CYSTEINYL)-7E,9E,11Z,14Z-EICOSATETRAENOIC ACID
• N-ACETYL LEUKOTRIENE E4
• (5S,6R,7E,9E,11Z,14Z)-5-Hydroxy-6-[[(R)-2-acetylamino-2-carboxyethyl]thio]-7,9,11,14-icosatetraenoic acid

N-acetyl Leukotriene E4

CAS: 80115-95-3

N-acetyl Leukotriene E4 is an endogenous metabolite of Leukotriene E4, less active than Leukotriene E4, causing constriction of the airways.

Formula: C₂₅H₃₉NO₆S

Color and Shape: Solid

Molecular weight: 481.65

Ref: TM-T38062