CAS 80195-36-4

Cefdaloxime

Description:

Cefdaloxime is a broad-spectrum cephalosporin antibiotic that is primarily used to treat bacterial infections. It belongs to the beta-lactam class of antibiotics, which work by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Cefdaloxime is effective against a variety of Gram-positive and Gram-negative bacteria, making it useful in treating respiratory tract infections, skin infections, and urinary tract infections. The compound is typically administered via injection and is characterized by its stability against certain beta-lactamases, which are enzymes produced by some bacteria to resist antibiotic action. Its chemical structure includes a beta-lactam ring, which is essential for its antibacterial activity. Cefdaloxime is generally well-tolerated, but like all antibiotics, it may cause side effects, including allergic reactions and gastrointestinal disturbances. As with any antibiotic, it is crucial to use cefdaloxime judiciously to prevent the development of antibiotic resistance.

Formula: C₁₄H₁₅N₅O₆S₂

InChI: InChI=1S/C14H15N5O6S2/c1-25-2-5-3-26-12-8(11(21)19(12)9(5)13(22)23)17-10(20)7(18-24)6-4-27-14(15)16-6/h4,8,12,24H,2-3H2,1H3,(H2,15,16)(H,17,20)(H,22,23)/b18-7-/t8-,12-/m1/s1

InChI key: InChIKey=HOGISBSFFHDTRM-GHXIOONMSA-N

SMILES: C(O)(=O)C=1N2[C@@]([C@H](NC(/C(=N\O)/C3=CSC(N)=N3)=O)C2=O)(SCC1COC)[H]

Synonyms:

• (+)-(6R,7R)-7-(2-(2-Amino-4-thiazolyl)glyoxylamido)-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid, 7(sup 2)-(Z)-oxime
• (6R,7R)-7-[[(2Z)-2-(2-Amino-4-thiazolyl)-2-(hydroxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• (6R,7R)-7-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-(hydroxyimino)acetyl]amino}-3-(methoxymethyl)-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2-amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, [6R-[6α,7β(Z)]]-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-(2-amino-4-thiazolyl)(hydroxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, (6R,7R)-
• 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2Z)-2-(2-amino-4-thiazolyl)-2-(hydroxyimino)acetyl]amino]-3-(methoxymethyl)-8-oxo-, (6R,7R)-
• Cefdaloxima
• Cefdaloxima [INN-Spanish]
• Cefdaloxime [INN]
• Cefdaloximum
• Cefdaloximum [INN-Latin]
• Ru 29246
• Unii-6856Hdt30F

Cefdaloxime

CAS: 80195-36-4

Ref: 7W-GA2078

Cefdaloxime

Controlled Product

CAS: 80195-36-4

Applications Cefdaloxime is an orally administered cephalosporin that has activity against Haemophilus influenzae, a bacteria that causes meningitis in humans. Cefdaloxime is also the active metabolite of HR916K, a cephalosporin ester.
References Jones, R. & Erwin, M.: Diag. Micro. Infect. Dis., 15, 693 (1992); Jones, R. & Erwin, M.: J. Clin. Micro., 30, 1297 (1992); Käyhty, R., et al.: J. Infect. Dis., 147, 1100 (1983)

Formula: C₁₄H₁₅N₅O₆S₂

Color and Shape: Light Yellow To Beige

Molecular weight: 413.429

Ref: TR-C242600

Cefdaloxime

CAS: 80195-36-4

Cefdaloxime is a fluoroquinolone antibiotic that is used to treat bacterial infections. It has a breakpoint of 8, which means it will be effective against organisms with an MIC of up to 8. Cefdaloxime is degradable and orally active, which makes it suitable for treating patients who cannot take injections or have difficulty swallowing tablets. This drug binds to receptor binding sites on the cell wall of gram-negative bacteria, and can also bind to affinity ligands in the cell membrane of gram-positive bacteria. Cefdaloxime may be used as an antimicrobial agent against resistant microorganisms such as Enterococcus faecium, Enterococcus faecalis, Staphylococcus aureus and Klebsiella pneumoniae.

Formula: C₁₄H₁₅N₅O₆S₂

Purity: Min. 95%

Molecular weight: 413.4 g/mol

Ref: 3D-FDA19536